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Motilin

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{{#if: | {{#if: | {{#if:7141| {{#if: 22 Aminosäuren | {{#if: | {{#if: | {{#if: Promotilin (115 AS) | {{#if: | {{#if: MLNP12872158270 | {{#if: MLN | {{#if: P12872158270 | {{#if: | {{#if:| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: Eutheria{{#if: P12872 | {{#ifeq: Motilin precursor | NV ||1}}|}}| {{#if: P12872 | {{#ifeq: Motilin precursor | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Eutheria | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: | }}
{{#if: | | Motilin }}
Motilin }}
Bänder/Stäbchenmodell nach PDB 1LBJ
Motilin }}
Andere Namen

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Vorhandene Strukturdaten: }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 22 Aminosäuren

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Sekundär- bis Quartärstruktur

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Kofaktor

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Präkursor Promotilin (115 AS)

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Isoformen

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Bezeichner
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Externe IDs

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Arzneistoffangaben
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Transporter-Klassifikation
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Vorkommen
{{#if: Motilin precursor|Hovergen}}] Motilin precursor|Hovergen}}]}} }} }}
Eutheria }}
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{{#if:Motilin-1LBJ.png||}}

Motilin ist ein gastrointestinales Peptidhormon, das in den M-Zellen des Dünndarms (deren Zahl abnehmend von Duodenum zu Ileum) gebildet wird und gemeinsam mit Ghrelin ausgeschüttet wird. Das Peptid besteht aus 22 Aminosäuren.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P12872}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Funktion

Durch Andocken an den Motilinrezeptor (in Mucosa, Plexus myentericus, Dünndarm-Muskulatur, Purkinje-Zellen) löst Motilin im Magen und Darm interdigestive Motilität aus. Gallensteinpatienten hatten in einer chinesischen Studie erhöhte Blut-Motilin-Werte. Motilin spielt möglicherweise eine Rolle bei der Reaktion des Körpers auf Akupunktur. Über die Funktion in Purkinje-Zellen ist noch nichts bekannt.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Regulation

Stimulus zur Sekretion: fettreiche Mahlzeiten, Magendehnung, Galle und pH-Abfall im Duodenum. Die Kontrolle der Sekretion geschieht auch neuronal und durch Serotonin.

Bestimmte Antibiotika (Makrolide) wirken am Motilinrezeptor als Agonisten und lösen so gastrointestinale Störungen aus.

Einzelnachweise

<references />

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