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Transkriptionsfaktor IIF

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{{#if: DNA-abhängige Polymerase II-Gesamtkomplex | |-
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DNA-abhängige Polymerase II-Gesamtkomplex }}

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Gene Ontology
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Transkriptionsfaktor IIF (TFIIF) ist ein Proteinkomplex im Zellkern von Wirbeltieren, der unentbehrlich für die Initiation der Transkription aller Gene ist. Insbesondere bindet TFIIF an die RNA-Polymerase II und stabilisiert den TFIID-TFIIA-TFIIB-Komplex und trägt so zur genauen Positionierung des Präinitiationskomplexes am Genanfang bei. Weitere Funktionen von TFIIF während der Elongationsphase sind inzwischen bekannt.<ref>Reinberg/reactome: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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TFIIF besteht aus zwei Untereinheiten (RAP74, RAP30) mit 517 und 249 Aminosäuren. Die zweite Untereinheit besitzt Helikase-Aktivität (EC 3.6.1.-). RAP74 bindet an FCP1, die für das Recycling der Polymerase notwendig ist. RAP74 interagiert außerdem mit TAF6 und RAP30 mit HTATSF1 sowie mit GPBP1.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P35269}}{{#if:|Vorlage:Abrufdatum}}, {{#if: | | UniProt }} {{#if:|{{{titel}}}|P13984}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Einzelnachweise

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