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Prostacyclinsynthase

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{{#if: | {{#if: PDB 2iag, 3b6h| {{#if:9603| {{#if: 57,1 Kilodalton / 500 Aminosäuren | {{#if: single pass Membranprotein | {{#if: Häm-Thiolat | {{#if: | {{#if: | {{#if: PTGISCYP8A1Q166476016991097156 | {{#if: PTGISCYP8A1 | {{#if: Q166476016991097156 | {{#if: | {{#if:| {{#if: | {{#if: 5.3.99.4IsomeraseUmlagerungProstaglandin H2Prostacyclin | {{#if: 5.3.99.4Isomerase| {{#if: | {{#if: | {{#if: Umlagerung| {{#if: Prostaglandin H2| {{#if: Prostacyclin| {{#if: Wirbeltiere{{#if: Q16647 | {{#ifeq: | NV ||1}}|}}| {{#if: Q16647 | {{#ifeq: | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Wirbeltiere | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000124212ENSMUSG00000017969
{{#if: | | Prostacyclinsynthase }}
Prostacyclinsynthase }}
Bändermodell mit Häm im Zentrum (Kalotten) nach PDB 2IAG
Prostacyclinsynthase }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: PDB 2iag, 3b6h }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 57,1 Kilodalton / 500 Aminosäuren

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Sekundär- bis Quartärstruktur single pass Membranprotein

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Kofaktor Häm-Thiolat

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Präkursor

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Isoformen

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Bezeichner
{{#if:CYP8A1 | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:9603 | PTGIS | PTGIS}}{{#if:CYP8A1 |, CYP8A1}} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

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all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

 }}

}}

Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [1] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [2] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:5.3.99.4| 5.3.99.4}}{{#if: Isomerase|, Isomerase}} }}
MEROPS [3]}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart Umlagerung 
 }}
Substrat Prostaglandin H2 
 }}
Produkte Prostacyclin 
 }}


}}

Vorkommen
{{#if: [ {{#if: Hovergen}}] [http://hogenom.univ-lyon1.fr/query_sequence?seq=Q16647 {{#if: Hovergen}}]}} }} }}
Wirbeltiere }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 5740
5740 }} 
 {{ #if: 19223
19223 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000124212
ENSG00000124212 }} 
    {{ #if: ENSMUSG00000017969
ENSMUSG00000017969 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q16647
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q16647}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: O35074
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|O35074}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000961NM_008968
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000961
         | | NM_000961
         | |  }}
      {{ #if: NM_008968
         | | NM_008968
         | |  }}
    |}}
 |-
 {{#if: NP_000952NP_032994
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000952
         | | NP_000952
         | |  }}
      {{ #if: NP_032994
         | | NP_032994
         | |  }}
    |}}
 |-
 {{#if: 2049503874495681462167191805167240604
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 20 
        | {{#if: 49503874 
            | {{#if: 49568146 
                | |  #if: hg38 |?db=hg38|}}&position=chr20:49503874-49568146 Chr 20: {{#expr: 49503874 / 1000000 round 2}} – {{#expr: 49568146 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 2 
        | {{#if: 167191805 
            | {{#if: 167240604 
                | |  #if: mm10 |?db=mm10|}}&position=chr2:167191805-167240604 Chr 2: {{#expr: 167191805 / 1000000 round 2}} – {{#expr: 167240604 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 5740
    | | 5740
    | |  }}
 {{ #if: 19223
    | | 19223
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 5740 

 {{#if: ENSG00000124212
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000124212 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q16647}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000961
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000961 }} 

 {{#if: NP_000952
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000952 }} 

 {{#if: 20 
   | {{#if: 49503874 
       | {{#if: 49568146 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr20:49503874-49568146 Chr 20: {{#expr: 49503874 / 1000000 round 2}} – {{#expr: 49568146 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 5740 }} {{#if: Hausmaus 

    | {{#if: 19223ENSMUSG00000017969NM_008968NP_032994mm102167191805167240604O35074 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 19223ENSMUSG00000017969NM_008968NP_032994mm102167191805167240604O35074 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 5740
    | | 5740
    | |  }}
 {{ #if: 19223
    | | 19223
    | |  }}
 |-
 {{#if: ENSG00000124212ENSMUSG00000017969
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000124212
       || ENSG00000124212
       ||  }}
    {{ #if: ENSMUSG00000017969
       || ENSMUSG00000017969
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q16647
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q16647}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: O35074
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|O35074}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000961NM_008968
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000961
         | | NM_000961
         | |  }}
      {{ #if: NM_008968
         | | NM_008968
         | |  }}
    |}}
 |-
 {{#if: NP_000952NP_032994
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000952
         | | NP_000952
         | |  }}
      {{ #if: NP_032994
         | | NP_032994
         | |  }}
    |}}
 |-
 {{#if: 2049503874495681462167191805167240604
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 20 
        | {{#if: 49503874 
            | {{#if: 49568146 
                | |  #if: hg38 |?db=hg38|}}&position=chr20:49503874-49568146 Chr 20: {{#expr: 49503874 / 1000000 round 2}} – {{#expr: 49568146 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 2 
        | {{#if: 167191805 
            | {{#if: 167240604 
                | |  #if: mm10 |?db=mm10|}}&position=chr2:167191805-167240604 Chr 2: {{#expr: 167191805 / 1000000 round 2}} – {{#expr: 167240604 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 5740
    | | 5740
    | |  }}
 {{ #if: 19223
    | | 19223
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 5740 

 {{#if: ENSG00000124212
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000124212 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q16647}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000961
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000961 }} 

 {{#if: NP_000952
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000952 }} 

 {{#if: 20 
   | {{#if: 49503874 
       | {{#if: 49568146 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr20:49503874-49568146 Chr 20: {{#expr: 49503874 / 1000000 round 2}} – {{#expr: 49568146 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 5740 }} {{#if: Hausmaus 

    | {{#if: 19223ENSMUSG00000017969NM_008968NP_032994mm102167191805167240604O35074 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 19223ENSMUSG00000017969NM_008968NP_032994mm102167191805167240604O35074 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:Prostacyclin_synthase_2IAG_Chiang_et_al.png||}}

Prostacyclinsynthase (Gen: PTGIS) ist das Enzym, das die Umlagerung von Prostaglandin H2 nach Prostacyclin katalysiert. Diese Reaktion ist das Gegengewicht zur Umwandlung nach Thromboxan A2, und auch die Reaktionsprodukte sind physiologische Gegenspieler. Die Synthase kommt in Wirbeltieren vor. Beim Menschen ist sie als Membranprotein in allen Gewebetypen, besonders aber in Ovarien, Herz, Skelettmuskeln, Lunge und Prostata zu finden.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|Q16647}}{{#if:|Vorlage:Abrufdatum}}</ref>

Prostacyclinsynthase ist in der Membran des endoplasmatischen Reticulums auf der Innenseite lokalisiert und ist über ein Fusionsprotein eng assoziiert mit den Enzymen COX-1/COX-2. Als Gegenspieler einer Thromboxan A2-erzeugten Thrombose ist die Prostacyclinsynthase ein gentherapeutisches Target für die Behandlung der pulmonalen Hypertonie.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Katalysierte Reaktion

PGH2  ⇒  PGI2

Prostaglandin H2 wird zu Prostaglandin I2 (Prostacyclin) umgelagert.

Weitere Funktionen

Bestimmte Varianten der Prostacyclinsynthase waren assoziiert mit schwerem Verlauf einer Respiratory-Syncytial-Virus-Infektion japanischer Kinder.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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        | Vorlage:Cite book/Meldung
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    | Vorlage:Cite book/Meldung
  }}</ref>

Regulation

Signaltransduktion von Tretinoin über den Retinsäure-Rezeptor erhöht die Expression von Prostacyclinsynthase. Enzymaktivität wird gehemmt durch Peroxynitrit, was durch Glutathion oder Vitamin C verhindert wird.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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    | Vorlage:Cite book/Meldung
  }}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 
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  }}</ref>

Weblinks

[[b:{{#if:|{{{lang}}}:}}{{#if:Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Prostacyclinsynthase}}|Wikibooks: {{#if:|{{{2}}}|{{#if:Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Prostacyclinsynthase}}}}]]{{#switch: 1

|1|= – Lern- und Lehrmaterialien |0|-= |X|x={{#switch: 0 

      |0|4|10|12|14|100=}}

|#default= – {{{suffix}}}

}}{{#if: | ({{#invoke:Multilingual|format|{{{lang}}}|slang=!|shift=m}}) }}

{{#invoke:TemplatePar|check 

  |opt= 1= 2= lang= suffix=
  |template=Vorlage:Wikibooks
  |cat=Wikipedia:Vorlagenfehler/Schwesterprojekt
  }}

Einzelnachweise

<references />

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