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Knochenmorphogenetisches Protein 1

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{{#if: | {{#if: 3EDG, 3EDH| {{#if:1067| {{#if: 866 Aminosäuren | {{#if: | {{#if: Zn2+, Ca2+ | {{#if: | {{#if: 7 | {{#if: BMP1P1349711226488176 | {{#if: BMP1 | {{#if: P1349711226488176 | {{#if: | {{#if:| {{#if: | {{#if: 3.4.24.19MetalloproteaseM12.005Spaltung von PeptidbindungenAla-+-Asp / Arg-+-Asp in Procollagen-I/II/III und Pro-ApoA1Collagen-I/II/III, ApoA1 | {{#if: 3.4.24.19Metalloprotease| {{#if: M12.005| {{#if: | {{#if: Spaltung von Peptidbindungen| {{#if: Ala-+-Asp / Arg-+-Asp in Procollagen-I/II/III und Pro-ApoA1| {{#if: Collagen-I/II/III, ApoA1| {{#if: mehrzellige Tiere<ref>Homologe bei OMA</ref>{{#if: P13497 | {{#ifeq: | NV ||1}}|}}| {{#if: P13497 | {{#ifeq: | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: mehrzellige Tiere<ref>Homologe bei OMA</ref> | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000168487ENSMUSG00000022098
{{#if: | | Knochenmorphogenetisches Protein 1 }}
Knochenmorphogenetisches Protein 1 }}
nach 3EDG
Knochenmorphogenetisches Protein 1 }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: 3EDG, 3EDH }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 866 Aminosäuren

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Sekundär- bis Quartärstruktur

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Kofaktor Zn2+, Ca2+

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Präkursor

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Isoformen 7

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:1067 | BMP1 | BMP1}}{{#if: |, }} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}} }}{{#invoke:TemplatePar|check

all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

 }}

}}

Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [1] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [2] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:3.4.24.19| 3.4.24.19}}{{#if: Metalloprotease|, Metalloprotease}} }}
MEROPS M12.005}}
MEROPS [3]}}
Reaktionsart Spaltung von Peptidbindungen 
 }}
Substrat Ala-+-Asp / Arg-+-Asp in Procollagen-I/II/III und Pro-ApoA1 
 }}
Produkte Collagen-I/II/III, ApoA1 
 }}


}}

Vorkommen
{{#if: [ {{#if: Hovergen}}] [http://hogenom.univ-lyon1.fr/query_sequence?seq=P13497 {{#if: Hovergen}}]}} }} }}
mehrzellige Tiere<ref>Homologe bei OMA</ref> }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 649
649 }} 
 {{ #if: 12153
12153 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000168487
ENSG00000168487 }} 
    {{ #if: ENSMUSG00000022098
ENSMUSG00000022098 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P13497
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P13497}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P98063
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P98063}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001199NM_009755
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001199
         | | NM_001199
         | |  }}
      {{ #if: NM_009755
         | | NM_009755
         | |  }}
    |}}
 |-
 {{#if: NP_001190NP_033885
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001190
         | | NP_001190
         | |  }}
      {{ #if: NP_033885
         | | NP_033885
         | |  }}
    |}}
 |-
 {{#if: 82216473622212326147047455770520260
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 8 
        | {{#if: 22164736 
            | {{#if: 22212326 
                | |  #if: hg38 |?db=hg38|}}&position=chr8:22164736-22212326 Chr 8: {{#expr: 22164736 / 1000000 round 2}} – {{#expr: 22212326 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 14 
        | {{#if: 70474557 
            | {{#if: 70520260 
                | |  #if: mm10 |?db=mm10|}}&position=chr14:70474557-70520260 Chr 14: {{#expr: 70474557 / 1000000 round 2}} – {{#expr: 70520260 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 649
    | | 649
    | |  }}
 {{ #if: 12153
    | | 12153
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 649 

 {{#if: ENSG00000168487
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000168487 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P13497}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001199
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001199 }} 

 {{#if: NP_001190
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001190 }} 

 {{#if: 8 
   | {{#if: 22164736 
       | {{#if: 22212326 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr8:22164736-22212326 Chr 8: {{#expr: 22164736 / 1000000 round 2}} – {{#expr: 22212326 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 649 }} {{#if: Hausmaus 

    | {{#if: 12153ENSMUSG00000022098NM_009755NP_033885mm10147047455770520260P98063 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 12153ENSMUSG00000022098NM_009755NP_033885mm10147047455770520260P98063 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 649
    | | 649
    | |  }}
 {{ #if: 12153
    | | 12153
    | |  }}
 |-
 {{#if: ENSG00000168487ENSMUSG00000022098
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000168487
       || ENSG00000168487
       ||  }}
    {{ #if: ENSMUSG00000022098
       || ENSMUSG00000022098
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P13497
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P13497}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P98063
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P98063}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001199NM_009755
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001199
         | | NM_001199
         | |  }}
      {{ #if: NM_009755
         | | NM_009755
         | |  }}
    |}}
 |-
 {{#if: NP_001190NP_033885
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001190
         | | NP_001190
         | |  }}
      {{ #if: NP_033885
         | | NP_033885
         | |  }}
    |}}
 |-
 {{#if: 82216473622212326147047455770520260
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 8 
        | {{#if: 22164736 
            | {{#if: 22212326 
                | |  #if: hg38 |?db=hg38|}}&position=chr8:22164736-22212326 Chr 8: {{#expr: 22164736 / 1000000 round 2}} – {{#expr: 22212326 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 14 
        | {{#if: 70474557 
            | {{#if: 70520260 
                | |  #if: mm10 |?db=mm10|}}&position=chr14:70474557-70520260 Chr 14: {{#expr: 70474557 / 1000000 round 2}} – {{#expr: 70520260 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 649
    | | 649
    | |  }}
 {{ #if: 12153
    | | 12153
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 649 

 {{#if: ENSG00000168487
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000168487 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P13497}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001199
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001199 }} 

 {{#if: NP_001190
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001190 }} 

 {{#if: 8 
   | {{#if: 22164736 
       | {{#if: 22212326 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr8:22164736-22212326 Chr 8: {{#expr: 22164736 / 1000000 round 2}} – {{#expr: 22212326 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 649 }} {{#if: Hausmaus 

    | {{#if: 12153ENSMUSG00000022098NM_009755NP_033885mm10147047455770520260P98063 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 12153ENSMUSG00000022098NM_009755NP_033885mm10147047455770520260P98063 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:3edg.png||}}

Knochenmorphogenetisches Protein 1 (BMP1) ist ein Protein, dessen Homologe in allen mehrzelligen Tieren nachgewiesen werden können. Beim Menschen hat BMP1 einerseits die Funktion eines Wachstumsfaktors, der die Differenzierung von Mesenchym-Zellen zu Osteoblasten auslösen kann, andererseits hat BMP1 enzymatische Aktivität: als Peptidase spaltet es die Vorstufen der Collagene I, II und III sowie von Apolipoprotein A1. Es ist daher wichtig für die Knorpelbildung und den reversen Cholesterintransport. BMP1 ist das einzige knochenmorphogenetische Protein, das nicht zur TGF-beta-Superfamilie (Transforming growth factor) von Zytokinen gehört. BMP1 gehört zu den Metalloproteasen.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P13497}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>H. Ibelgaufts/COPE: BMP</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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BMP1-Inhibitoren haben in Zell- und Tierstudien das Potenzial gezeigt, in Narbencremes eingesetzt zu werden.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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   |preview  = 1
  }}Vorlage:Cite book/URL{{#if:  | Vorlage:Cite book/Meldung }}{{#if:        | Vorlage:Cite book/Meldung }}{{#if: J. Biol. Chem.
     || Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
        | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
       | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}Vorlage:Cite book/Meldung2{{#ifexpr: 0{{#ifeq:^^|^^||+1}}{{#ifeq:^^|^^||+1}}{{#ifeq:Zhang Y, Ge G, Greenspan DS|^^||+1}}{{#ifeq:^^|^^||+1}} > 1
    | Vorlage:Cite book/Meldung
  }}</ref>

Weblinks

Einzelnachweise

<references />

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