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Insulysin

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{{#if: | {{#if: 2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL| {{#if:5381| {{#if: 1018 Aminosäuren | {{#if: Dimer; Oligomer | {{#if: Zn2+ | {{#if: | {{#if: | {{#if: IDEP1473514668096412 | {{#if: IDE | {{#if: P1473514668096412 | {{#if: | {{#if:| {{#if: | {{#if: 3.4.24.56MetalloproteaseM16.002Hochspezifische HydrolyseInsulinAbbauprodukte | {{#if: 3.4.24.56Metalloprotease| {{#if: M16.002| {{#if: | {{#if: Hochspezifische Hydrolyse| {{#if: Insulin| {{#if: Abbauprodukte| {{#if: Eukaryoten, Bakterien<ref>Homologe bei OMA</ref>{{#if: P14735 | {{#ifeq: | NV ||1}}|}}| {{#if: P14735 | {{#ifeq: | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Eukaryoten, Bakterien<ref>Homologe bei OMA</ref> | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000119912ENSMUSG00000056999
{{#if: | | Insulysin }}
Insulysin }}
Insulysin }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: 2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 1018 Aminosäuren

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Sekundär- bis Quartärstruktur Dimer; Oligomer

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Kofaktor Zn2+

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Präkursor

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Isoformen

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:5381 | IDE | IDE}}{{#if: |, }} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}} }}{{#invoke:TemplatePar|check

all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

 }}

}}

Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [1] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [2] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:3.4.24.56| 3.4.24.56}}{{#if: Metalloprotease|, Metalloprotease}} }}
MEROPS M16.002}}
MEROPS [3]}}
Reaktionsart Hochspezifische Hydrolyse 
 }}
Substrat Insulin 
 }}
Produkte Abbauprodukte 
 }}


}}

Vorkommen
{{#if: [ {{#if: Hovergen}}] [http://hogenom.univ-lyon1.fr/query_sequence?seq=P14735 {{#if: Hovergen}}]}} }} }}
Eukaryoten, Bakterien<ref>Homologe bei OMA</ref> }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 3416
3416 }} 
 {{ #if: 15925
15925 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000119912
ENSG00000119912 }} 
    {{ #if: ENSMUSG00000056999
ENSMUSG00000056999 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P14735
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P14735}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q8CGB9
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q8CGB9}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001165946NM_031156
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001165946
         | | NM_001165946
         | |  }}
      {{ #if: NM_031156
         | | NM_031156
         | |  }}
    |}}
 |-
 {{#if: NP_001159418NP_112419
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001159418
         | | NP_001159418
         | |  }}
      {{ #if: NP_112419
         | | NP_112419
         | |  }}
    |}}
 |-
 {{#if: 109245168492574076193726874337337852
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 10 
        | {{#if: 92451684 
            | {{#if: 92574076 
                | |  #if: hg38 |?db=hg38|}}&position=chr10:92451684-92574076 Chr 10: {{#expr: 92451684 / 1000000 round 2}} – {{#expr: 92574076 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 19 
        | {{#if: 37268743 
            | {{#if: 37337852 
                | |  #if: mm10 |?db=mm10|}}&position=chr19:37268743-37337852 Chr 19: {{#expr: 37268743 / 1000000 round 2}} – {{#expr: 37337852 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 3416
    | | 3416
    | |  }}
 {{ #if: 15925
    | | 15925
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 3416 

 {{#if: ENSG00000119912
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000119912 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P14735}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001165946
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001165946 }} 

 {{#if: NP_001159418
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001159418 }} 

 {{#if: 10 
   | {{#if: 92451684 
       | {{#if: 92574076 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr10:92451684-92574076 Chr 10: {{#expr: 92451684 / 1000000 round 2}} – {{#expr: 92574076 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 3416 }} {{#if: Hausmaus 

    | {{#if: 15925ENSMUSG00000056999NM_031156NP_112419mm10193726874337337852Q8CGB9 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 15925ENSMUSG00000056999NM_031156NP_112419mm10193726874337337852Q8CGB9 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 3416
    | | 3416
    | |  }}
 {{ #if: 15925
    | | 15925
    | |  }}
 |-
 {{#if: ENSG00000119912ENSMUSG00000056999
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000119912
       || ENSG00000119912
       ||  }}
    {{ #if: ENSMUSG00000056999
       || ENSMUSG00000056999
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P14735
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P14735}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q8CGB9
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q8CGB9}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001165946NM_031156
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001165946
         | | NM_001165946
         | |  }}
      {{ #if: NM_031156
         | | NM_031156
         | |  }}
    |}}
 |-
 {{#if: NP_001159418NP_112419
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001159418
         | | NP_001159418
         | |  }}
      {{ #if: NP_112419
         | | NP_112419
         | |  }}
    |}}
 |-
 {{#if: 109245168492574076193726874337337852
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 10 
        | {{#if: 92451684 
            | {{#if: 92574076 
                | |  #if: hg38 |?db=hg38|}}&position=chr10:92451684-92574076 Chr 10: {{#expr: 92451684 / 1000000 round 2}} – {{#expr: 92574076 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 19 
        | {{#if: 37268743 
            | {{#if: 37337852 
                | |  #if: mm10 |?db=mm10|}}&position=chr19:37268743-37337852 Chr 19: {{#expr: 37268743 / 1000000 round 2}} – {{#expr: 37337852 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 3416
    | | 3416
    | |  }}
 {{ #if: 15925
    | | 15925
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 3416 

 {{#if: ENSG00000119912
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000119912 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P14735}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001165946
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001165946 }} 

 {{#if: NP_001159418
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001159418 }} 

 {{#if: 10 
   | {{#if: 92451684 
       | {{#if: 92574076 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr10:92451684-92574076 Chr 10: {{#expr: 92451684 / 1000000 round 2}} – {{#expr: 92574076 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 3416 }} {{#if: Hausmaus 

    | {{#if: 15925ENSMUSG00000056999NM_031156NP_112419mm10193726874337337852Q8CGB9 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 15925ENSMUSG00000056999NM_031156NP_112419mm10193726874337337852Q8CGB9 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:Protein_IDE_PDB_2g47.png||}}

Insulysin (IDE) (auch: Insulin-abbauendes Enzym, früher: Insulinase) ist ein Enzym, das in Bakterien und Eukaryoten vorkommt. IDE ist in der Lage, in Wirbeltieren neben dem Protein Insulin mehrere andere extrazellulär auftretende Proteine wie beta-Amyloid und Somatostatin abzubauen und so unschädlich zu machen. IDE wird beim Menschen in allen Gewebetypen exprimiert.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P14735}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Studien an Han-Chinesen, Deutschen und Moskauern deuten auf eine Assoziation von Polymorphismen am IDE-Gen mit der Ausbildung eines metabolischen Syndroms und Diabetes mellitus Typ 2. Weiterhin sind niedrige Expressionswerte von IDE statistisch mit dem Auftreten der Alzheimer-Krankheit verbunden. Insulysin ist außerdem eine Eintrittspforte für die Infektion mit dem Varizella-Zoster-Virus.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Einzelnachweise

<references />

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