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Glucokinase-Regulator

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{{#if: | {{#if: | {{#if:4196| {{#if: 624 Aminosäuren | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: GCKRQ14397600842 | {{#if: GCKR | {{#if: Q14397600842 | {{#if: | {{#if:| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: Euteleostomi{{#if: Q14397 | {{#ifeq: Glucokinase-Regulator | NV ||1}}|}}| {{#if: Q14397 | {{#ifeq: Glucokinase-Regulator | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Euteleostomi | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000084734ENSMUSG00000059434
{{#if: | | Glucokinase-Regulator }}
[[Datei:|250x200px|{{#if: | | Glucokinase-Regulator }}]]
Glucokinase-Regulator }}
Andere Namen

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Vorhandene Strukturdaten: }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 624 Aminosäuren

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Sekundär- bis Quartärstruktur

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Kofaktor

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Präkursor

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Isoformen

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:4196 | GCKR | GCKR}}{{#if: |, }} }}
Externe IDs

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all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

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Arzneistoffangaben
ATC-Code 
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 {{#if:|
DrugBank [2] 
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 {{#if:|
Wirkstoffklasse 
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Transporter-Klassifikation
TCDB [3] 
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Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:| [4]}}{{#if: |, [[]]}} }}
MEROPS [5]}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart 
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Substrat 
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Produkte 
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Vorkommen
{{#if: Glucokinase-Regulator|Hovergen}}] Glucokinase-Regulator|Hovergen}}]}} }} }}
Euteleostomi }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 2646
2646 }} 
 {{ #if: 231103
231103 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000084734
ENSG00000084734 }} 
    {{ #if: ENSMUSG00000059434
ENSMUSG00000059434 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q14397
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q14397}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q91X44
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q91X44}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001486NM_144909
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001486
         | | NM_001486
         | |  }}
      {{ #if: NM_144909
         | | NM_144909
         | |  }}
    |}}
 |-
 {{#if: NP_001477NP_659158
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001477
         | | NP_001477
         | |  }}
      {{ #if: NP_659158
         | | NP_659158
         | |  }}
    |}}
 |-
 {{#if: 2274968392752368953129724431327302
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 2 
        | {{#if: 27496839 
            | {{#if: 27523689 
                | |  #if:  |?db=|}}&position=chr2:27496839-27523689 Chr 2: {{#expr: 27496839 / 1000000 round 2}} – {{#expr: 27523689 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 5 
        | {{#if: 31297244 
            | {{#if: 31327302 
                | |  #if:  |?db=|}}&position=chr5:31297244-31327302 Chr 5: {{#expr: 31297244 / 1000000 round 2}} – {{#expr: 31327302 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 2646
    | | 2646
    | |  }}
 {{ #if: 231103
    | | 231103
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 2646 

 {{#if: ENSG00000084734
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000084734 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q14397}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001486
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001486 }} 

 {{#if: NP_001477
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001477 }} 

 {{#if: 2 
   | {{#if: 27496839 
       | {{#if: 27523689 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chr2:27496839-27523689 Chr 2: {{#expr: 27496839 / 1000000 round 2}} – {{#expr: 27523689 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 2646 }} {{#if: Hausmaus 

    | {{#if: 231103ENSMUSG00000059434NM_144909NP_65915853129724431327302Q91X44 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 231103ENSMUSG00000059434NM_144909NP_65915853129724431327302Q91X44 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 2646
    | | 2646
    | |  }}
 {{ #if: 231103
    | | 231103
    | |  }}
 |-
 {{#if: ENSG00000084734ENSMUSG00000059434
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000084734
       || ENSG00000084734
       ||  }}
    {{ #if: ENSMUSG00000059434
       || ENSMUSG00000059434
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q14397
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q14397}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q91X44
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q91X44}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001486NM_144909
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001486
         | | NM_001486
         | |  }}
      {{ #if: NM_144909
         | | NM_144909
         | |  }}
    |}}
 |-
 {{#if: NP_001477NP_659158
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001477
         | | NP_001477
         | |  }}
      {{ #if: NP_659158
         | | NP_659158
         | |  }}
    |}}
 |-
 {{#if: 2274968392752368953129724431327302
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 2 
        | {{#if: 27496839 
            | {{#if: 27523689 
                | |  #if:  |?db=|}}&position=chr2:27496839-27523689 Chr 2: {{#expr: 27496839 / 1000000 round 2}} – {{#expr: 27523689 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 5 
        | {{#if: 31297244 
            | {{#if: 31327302 
                | |  #if:  |?db=|}}&position=chr5:31297244-31327302 Chr 5: {{#expr: 31297244 / 1000000 round 2}} – {{#expr: 31327302 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 2646
    | | 2646
    | |  }}
 {{ #if: 231103
    | | 231103
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 2646 

 {{#if: ENSG00000084734
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000084734 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q14397}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001486
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001486 }} 

 {{#if: NP_001477
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001477 }} 

 {{#if: 2 
   | {{#if: 27496839 
       | {{#if: 27523689 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chr2:27496839-27523689 Chr 2: {{#expr: 27496839 / 1000000 round 2}} – {{#expr: 27523689 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 2646 }} {{#if: Hausmaus 

    | {{#if: 231103ENSMUSG00000059434NM_144909NP_65915853129724431327302Q91X44 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 231103ENSMUSG00000059434NM_144909NP_65915853129724431327302Q91X44 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:||}}

Das Protein mit dem Namen Glucokinase-Regulator (GCKR) wird beim Menschen und allen Wirbeltieren in der Leber und der Bauchspeicheldrüse gebildet. GCKR bindet reversibel an das Enzym Glucokinase. Nach Translokation in den Zellkern wird der Komplex bei hohem Glukosespiegel getrennt und die Glucokinase wieder ins Zytosol geschafft. Der Effekt ist, dass bei niedrigem Glukosespiegel ein Pool an GK:GCKR im Nukleus bereitsteht, um schnell erhöhte Glukosewerte nach Nahrungsaufnahme abzufangen.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|Q14397}}{{#if:|Vorlage:Abrufdatum}}</ref><ref name='r'>reactome.org: Negative Regulation of Glucokinase by Glucokinase Regulatory Protein</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Die Bindung wird stimuliert durch Fructose-6-phosphat und Sorbitol-6-phosphat, aber behindert durch Fructose-1-phosphat. Letzteres erhöht also die Glucokinase-Aktivität.<ref name='r' />

Eine genetische Variante des Proteins, die in 34 Prozent von Nichteuropäern vorkommt, ist assoziiert mit erhöhtem CRP und Triglyceriden, sowie erniedrigter Glukose während des Fastens. Eine weitere Studie mit europäischstämmigen Kanadiern assoziierte erhöhte Triglyceride während des Fastens mit einer GCKR-Variante. Eine französische Studie brachte identische Ergebnisse.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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     | Vorlage:Cite book/Meldung
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    | Vorlage:Cite book/Meldung
  }}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 
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        | Vorlage:Cite book/Meldung
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     | Vorlage:Cite book/Meldung
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     | Vorlage:Cite book/Meldung
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     | Vorlage:Cite book/Meldung
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       | Vorlage:Cite book/Meldung
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     | Vorlage:Cite book/Meldung
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    | Vorlage:Cite book/Meldung
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  }}{{#if: Vorlage:Cite book/ParamBool
        | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
       | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
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    | Vorlage:Cite book/Meldung
  }}</ref>

Einzelnachweise

<references />

Abgerufen von „https://wiki-de.moshellshocker.dns64.de/index.php?title=Glucokinase-Regulator&oldid=1520023“