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GLUT-3

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{{#if: | {{#if: | {{#if:11107| {{#if: 496 Aminosäuren | {{#if: multipass (12 TMS) Membranprotein | {{#if: | {{#if: | {{#if: | {{#if: SLC2A3P11169138170 | {{#if: SLC2A3 | {{#if: P11169138170 | {{#if: | {{#if:| {{#if: 2.A.1.1.12| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: mehrzellige Tiere<ref>InterPro: Glucose transporter, type 3 (GLUT3)</ref>{{#if: P11169 | {{#ifeq: | NV ||1}}|}}| {{#if: P11169 | {{#ifeq: | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: mehrzellige Tiere<ref>InterPro: Glucose transporter, type 3 (GLUT3)</ref> | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: | }}
{{#if: | | GLUT-3 }}
[[Datei:|250x200px|{{#if: | | GLUT-3 }}]]
GLUT-3 }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 496 Aminosäuren

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Sekundär- bis Quartärstruktur multipass (12 TMS) Membranprotein

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Kofaktor

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Präkursor

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Isoformen

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:11107 | SLC2A3 | SLC2A3}}{{#if: |, }} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

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 }}

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Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [2] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

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Transporter-Klassifikation
TCDB 2.A.1.1.12 
 {{#if: Major-Facilitator-Superfamilie / Glucosetransporter|
Bezeichnung Major-Facilitator-Superfamilie / Glucosetransporter 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:| {{{EC-Nummer}}}}}{{#if: |, [[{{{Kategorie}}}]]}} }}
MEROPS {{{Peptidase_fam}}}}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart {{{Reaktionsart}}} 
 }}
Substrat {{{Substrat}}} 
 }}
Produkte {{{Produkte}}} 
 }}


}}

Vorkommen
{{#if: [ {{#if: Hovergen}}] [http://hogenom.univ-lyon1.fr/query_sequence?seq=P11169 {{#if: Hovergen}}]}} }} }}
mehrzellige Tiere<ref>InterPro: Glucose transporter, type 3 (GLUT3)</ref> }}
}}

}}

{{#if:||}}

GLUT-3 (Glucosetransporter Typ 3) (Gen: SLC2A3) heißt das Protein, das besonders in der Zellmembran der Neuronen von Tieren lokalisiert ist und die Ein- bzw. Ausschleusung von Glucose sowie von Dehydroascorbat erleichtert. Es handelt sich um ein Membran-Transportprotein. Beim Menschen ist GLUT-3 in geringem Maß auch in vielen anderen Gewebetypen vorhanden. Bei der Hausmaus (Mus musculus) ist es eines der häufigsten Proteine in den Spermien.<ref name='u'>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P11168}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>InterPro: IPR002945 Glucose transporter, type 3 (GLUT3)</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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    | Vorlage:Cite book/Meldung
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Das entwicklungsgeschichtlich älteste Exemplar wurde in Nematostella vectensis, einer Seeanemone gefunden.

Funktion

In Neuronen wird die Expression von GLUT-3 durch Aktivität der AMP-Kinase reguliert. Dieser Prozess ist ein wichtiger Teil der Unempfindlichkeit von Neuronen gegenüber Excitotoxizität (Überaktivierung von Glutamatrezeptoren). Auch in der frühen Entwicklungsphase des Embryos ist GLUT-3 unentbehrlich.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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    | Vorlage:Cite book/Meldung
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Weiterführende Literatur

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   |cat      = Wikipedia:Vorlagenfehler/Vorlage:Cite journal
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  }}Vorlage:Cite book/URL{{#if:  | Vorlage:Cite book/Meldung }}{{#if:        | Vorlage:Cite book/Meldung }}{{#if: J. Biol. Chem.
     || Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
        | Vorlage:Cite book/Meldung
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       | Vorlage:Cite book/Meldung
  }}{{#if: Vorlage:Cite book/ParamBool
     | Vorlage:Cite book/Meldung
  }}Vorlage:Cite book/Meldung2{{#ifexpr: 0{{#ifeq:^^|^^||+1}}{{#ifeq:^^|^^||+1}}{{#ifeq:Maulén NP, Henríquez EA, Kempe S, et al.|^^||+1}}{{#ifeq:^^|^^||+1}} > 1
    | Vorlage:Cite book/Meldung
  }}
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    | Vorlage:Cite book/Meldung
  }}
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    | Vorlage:Cite book/Meldung
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Weblinks

Einzelnachweise

<references />

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