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Aromatische-L-Aminosäure-Decarboxylase – Wikipedia Zum Inhalt springen

Aromatische-L-Aminosäure-Decarboxylase

aus Wikipedia, der freien Enzyklopädie
(Weitergeleitet von DOPA-Decarboxylase)
{{#if: | {{#if: 3RBF, 3RBL, 3RCH| {{#if:2719| {{#if: 338 bis 480 Aminosäuren (je nach Isoform) | {{#if: Homodimer | {{#if: Pyridoxalphosphat | {{#if: | {{#if: 4 | {{#if: DDCAADCP20711107930 | {{#if: DDCAADC | {{#if: P20711107930 | {{#if: | {{#if:| {{#if: | {{#if: 4.1.1.28LyaseDecarboxylierungDOPA, L-5-Hydroxy-Trp, L-TrpDopamin, Serotonin, Tryptamin + CO2 | {{#if: 4.1.1.28Lyase| {{#if: | {{#if: | {{#if: Decarboxylierung| {{#if: DOPA, L-5-Hydroxy-Trp, L-Trp| {{#if: Dopamin, Serotonin, Tryptamin + CO2| {{#if: Chordatiere{{#if: P20711 | {{#ifeq: AADC | NV ||1}}|}}| {{#if: P20711 | {{#ifeq: AADC | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Chordatiere | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000132437ENSMUSG00000020182
{{#if: | | Aromatische-L-Aminosäure-Decarboxylase }}
Aromatische-L-Aminosäure-Decarboxylase }}
dimer, Human
Aromatische-L-Aminosäure-Decarboxylase }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: 3RBF, 3RBL, 3RCH }}

Eigenschaften des menschlichen Proteins

}}

Masse/Länge Primärstruktur 338 bis 480 Aminosäuren (je nach Isoform)

}}

Sekundär- bis Quartärstruktur Homodimer

}}

Kofaktor Pyridoxalphosphat

}}

Präkursor

}}

Isoformen 4

}}

Bezeichner
{{#if:AADC | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:2719 | DDC | DDC}}{{#if:AADC |, AADC}} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}} }}{{#invoke:TemplatePar|check

all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

 }}

}}

Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [2] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [3] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:4.1.1.28| 4.1.1.28}}{{#if: Lyase|, Lyase}} }}
MEROPS [4]}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart Decarboxylierung 
 }}
Substrat DOPA, L-5-Hydroxy-Trp, L-Trp 
 }}
Produkte Dopamin, Serotonin, Tryptamin + CO2 
 }}


}}

Vorkommen
{{#if: AADC|Hovergen}}] AADC|Hovergen}}]}} }} }}
Chordatiere }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 1644
1644 }} 
 {{ #if: 13195
13195 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000132437
ENSG00000132437 }} 
    {{ #if: ENSMUSG00000020182
ENSMUSG00000020182 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P20711
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P20711}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: O88533
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|O88533}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000790NM_001190448
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000790
         | | NM_000790
         | |  }}
      {{ #if: NM_001190448
         | | NM_001190448
         | |  }}
    |}}
 |-
 {{#if: NP_000781NP_001177377
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000781
         | | NP_000781
         | |  }}
      {{ #if: NP_001177377
         | | NP_001177377
         | |  }}
    |}}
 |-
 {{#if: 75045843650565457111181410111898144
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 7 
        | {{#if: 50458436 
            | {{#if: 50565457 
                | |  #if: hg38 |?db=hg38|}}&position=chr7:50458436-50565457 Chr 7: {{#expr: 50458436 / 1000000 round 2}} – {{#expr: 50565457 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 11 
        | {{#if: 11814101 
            | {{#if: 11898144 
                | |  #if: mm10 |?db=mm10|}}&position=chr11:11814101-11898144 Chr 11: {{#expr: 11814101 / 1000000 round 2}} – {{#expr: 11898144 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 1644
    | | 1644
    | |  }}
 {{ #if: 13195
    | | 13195
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 1644 

 {{#if: ENSG00000132437
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000132437 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P20711}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000790
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000790 }} 

 {{#if: NP_000781
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000781 }} 

 {{#if: 7 
   | {{#if: 50458436 
       | {{#if: 50565457 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr7:50458436-50565457 Chr 7: {{#expr: 50458436 / 1000000 round 2}} – {{#expr: 50565457 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 1644 }} {{#if: Hausmaus 

    | {{#if: 13195ENSMUSG00000020182NM_001190448NP_001177377mm10111181410111898144O88533 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 13195ENSMUSG00000020182NM_001190448NP_001177377mm10111181410111898144O88533 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 1644
    | | 1644
    | |  }}
 {{ #if: 13195
    | | 13195
    | |  }}
 |-
 {{#if: ENSG00000132437ENSMUSG00000020182
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000132437
       || ENSG00000132437
       ||  }}
    {{ #if: ENSMUSG00000020182
       || ENSMUSG00000020182
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P20711
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P20711}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: O88533
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|O88533}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000790NM_001190448
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000790
         | | NM_000790
         | |  }}
      {{ #if: NM_001190448
         | | NM_001190448
         | |  }}
    |}}
 |-
 {{#if: NP_000781NP_001177377
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000781
         | | NP_000781
         | |  }}
      {{ #if: NP_001177377
         | | NP_001177377
         | |  }}
    |}}
 |-
 {{#if: 75045843650565457111181410111898144
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 7 
        | {{#if: 50458436 
            | {{#if: 50565457 
                | |  #if: hg38 |?db=hg38|}}&position=chr7:50458436-50565457 Chr 7: {{#expr: 50458436 / 1000000 round 2}} – {{#expr: 50565457 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 11 
        | {{#if: 11814101 
            | {{#if: 11898144 
                | |  #if: mm10 |?db=mm10|}}&position=chr11:11814101-11898144 Chr 11: {{#expr: 11814101 / 1000000 round 2}} – {{#expr: 11898144 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 1644
    | | 1644
    | |  }}
 {{ #if: 13195
    | | 13195
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 1644 

 {{#if: ENSG00000132437
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000132437 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P20711}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000790
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000790 }} 

 {{#if: NP_000781
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000781 }} 

 {{#if: 7 
   | {{#if: 50458436 
       | {{#if: 50565457 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr7:50458436-50565457 Chr 7: {{#expr: 50458436 / 1000000 round 2}} – {{#expr: 50565457 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 1644 }} {{#if: Hausmaus 

    | {{#if: 13195ENSMUSG00000020182NM_001190448NP_001177377mm10111181410111898144O88533 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 13195ENSMUSG00000020182NM_001190448NP_001177377mm10111181410111898144O88533 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:3rbf.jpg||}}

Aromatische-L-Aminosäure-Decarboxylase (AADC), auch DOPA-Decarboxylase (DDC) genannt, ist der Name für Enzyme in Chordatieren, die die Biosynthese von Dopamin, Serotonin und Tryptamin mittels Decarboxylierung katalysieren. Als Entdecker gilt der deutsche Pharmakologe Peter Holtz.

Mutationen am entsprechenden DDC-Gen und folgender Mangel am Enzym führen zu Mangel an den entsprechenden Neurotransmittern und Katecholaminen.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P20711}}{{#if:|Vorlage:Abrufdatum}}</ref> AADC ist gentherapeutisches Target für die Behandlung der Parkinson-Krankheit; Phase I-Studien wurden 2008 erfolgreich abgeschlossen. Patienten mit polyendokriner Autoimmunerkrankung Typ I (APS1) zeigen zum Teil Autoantikörper auf AADC. Manche Varianten der AADC sind assoziiert mit Nikotinabhängigkeit.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Katalysierte Reaktionen

L-DOPA ⇒ Dopamin + CO2

L-DOPA wird zu Dopamin decarboxyliert (Katecholamin-Synthese).

L-5-Hydroxy-Trp ⇒ Serotonin + CO2

5-Hydroxy-L-Tryptophan wird zu Serotonin decarboxyliert.

L-Trp ⇒ Tryptamin + CO2

L-Tryptophan wird zu Tryptamin decarboxyliert.

L-His ⇒ Histamin + CO2

L-Histidin wird zu Histamin decarboxyliert.

L-Tyrosin ⇒ Tyramin + CO2

L-Tyrosin wird zu Tyramin decarboxyliert (Tyrosin-Abbau).

L-Phe ⇒ Phenethylamin + CO2

L-Phenylalanin wird zu Phenethylamin decarboxyliert (L-Phe-Abbau).

Weitere Funktionen

Obwohl allgegenwärtig im Körper, zeigte eine Studie mit Mäusen besonders hohe Konzentrationen an AADC in Nieren und Darm, und festgestellte Unterschiede in der Nieren-Konzentration zwischen Männchen und Weibchen könnten für entsprechende Geschlechtsunterschiede im Natriumhaushalt verantwortlich sein. Es ist wichtig für die Entwicklung der Geschmacksknospen in Mäusen.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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AADC spielt eine Rolle im Signalweg des Androgenrezeptors.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Einzelnachweise

<references />

Weblinks

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