Homöoboxprotein DLX-3
(Weitergeleitet von DLX3)
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{{#if: 287 Aminosäuren |
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{{#if: DLX3O60479600525 |
{{#if: DLX3 |
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{{#if: Wirbeltiere<ref>Orthologe bei OMA</ref>{{#if: O60479 | {{#ifeq: | NV ||1}}|}}|
{{#if: O60479 | {{#ifeq: | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie
{{#if: Wirbeltiere<ref>Orthologe bei OMA</ref> | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon
{{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen
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| {{#if: | | Homöoboxprotein DLX-3 }} | |||||||||||||
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| Andere Namen |
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| Masse/Länge Primärstruktur | 287 Aminosäuren
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| Sekundär- bis Quartärstruktur |
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| {{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} | {{#if:2916 | DLX3 | DLX3}}{{#if: |, }} }} | ||||||||||||
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| Wirkstoffklasse | {{{Wirkstoffklasse}}}
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| {{#if: | [ {{#if: | Hovergen}}] | [http://hogenom.univ-lyon1.fr/query_sequence?seq=O60479 {{#if: | Hovergen}}]}} }} }} | |||||||||
| Wirbeltiere<ref>Orthologe bei OMA</ref> }} | |||||||||||||
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Das Homöobox-Protein DLX-3 (Gen-Name: DLX3) ist ein Protein, das in den Zellkernen von Wirbeltierzellen vorkommt. Als Transkriptionsfaktor wird es hauptsächlich während der Entwicklung des Vorderhirns exprimiert. Möglicherweise nimmt es auch an der Morphogenese des Schädels teil. Mutationen im DLX3-Gen wurden mit den autosomal-dominanten Leiden des Tricho-dento-osseous Syndroms und des Amelogenesis imperfecta mit Taurodontismus in Verbindung gebracht.<ref name="pmid7613049">{{#invoke:Vorlage:Literatur|f}}{{#if:
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Viele Homöobox enthaltende Gene der Wirbeltiere wurden anhand der Ähnlichkeit ihrer Sequenz zu den Entwicklungsgenen der Drosophila identifiziert. Mitglieder der DLX-Genfamilie enthalten eine Homöobox, die mit dem „Distal-less“ (Dll), einem Gen, das sich in Kopf und Gliedmaßen einer sich entwickelnden Fruchtfliege äußert, verwandt ist. Die „Distal-less“-Genfamilie (Dlx) umfasst mindestens sechs verschiedene Mitglieder, DLX1-DLX6. Das Gen befindet sich in einer Konfiguration mit anderen Vertretern der Genfamilie auf dem langen Arm von Chromosom 17.
Weblinks
- MeSH Homöoboxprotein DLX-3
- DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes. PMID 21252474.
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Einzelnachweise
<references />
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