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CREB-Binding-Protein – Wikipedia Zum Inhalt springen

CREB-Binding-Protein

aus Wikipedia, der freien Enzyklopädie
(Weitergeleitet von CREB Binding Protein)
{{#if: | {{#if: s. UniProt| {{#if:2348| {{#if: 2442 Aminosäuren | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: CREBBPQ92793600140 | {{#if: CREBBP | {{#if: Q92793600140 | {{#if: | {{#if:| {{#if: | {{#if: 2.3.1.48AcetyltransferaseÜbertragung einer AcetylgruppeHiston + Acetyl-CoAAcetylhiston + CoA | {{#if: 2.3.1.48Acetyltransferase| {{#if: | {{#if: | {{#if: Übertragung einer Acetylgruppe| {{#if: Histon + Acetyl-CoA| {{#if: Acetylhiston + CoA| {{#if: Euteleostomi{{#if: Q92793 | {{#ifeq: CREBBP | NV ||1}}|}}| {{#if: Q92793 | {{#ifeq: CREBBP | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Euteleostomi | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: | }}
{{#if: | | CREB-Binding-Protein }}
[[Datei:|250x200px|{{#if: | | CREB-Binding-Protein }}]]
CREB-Binding-Protein }}
Andere Namen

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Vorhandene Strukturdaten: s. UniProt }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 2442 Aminosäuren

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Sekundär- bis Quartärstruktur

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Kofaktor

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Präkursor

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Isoformen

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:2348 | CREBBP | CREBBP}}{{#if: |, }} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

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Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [2] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [3] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:2.3.1.48| 2.3.1.48}}{{#if: Acetyltransferase|, Acetyltransferase}} }}
MEROPS [4]}}
MEROPS [5]}}
Reaktionsart Übertragung einer Acetylgruppe 
 }}
Substrat Histon + Acetyl-CoA 
 }}
Produkte Acetylhiston + CoA 
 }}


}}

Vorkommen
{{#if: CREBBP|Hovergen}}] CREBBP|Hovergen}}]}} }} }}
Euteleostomi }}
}}

}}

{{#if:||}}

Das CREB-Binding Protein (CREB-Bindeprotein), kurz CBP, ist ein Coaktivator der Transkription.

CBP stellt eine Verbindung zwischen dem Transkriptionsfaktor CREB und dem Transkriptionsstartpunkt her, indem es als Histon-Acetyltransferase (HAT, EC 2.3.1.48) die Chromatin-Struktur verändert, die dadurch aufgelockert wird. CBP zeigt Homologien zum ebenfalls als HAT wirkenden Protein p300. CBP und p300 acetylieren bevorzugt die Histone H3 und H4.

CBP ist ein Coaktivator allgemeiner Natur und wechselwirkt z. B. auch mit Transkriptionsfaktoren.

Struktur

Datei:Structure CREBBP de.svg

Klinische Bedeutung

Mutationen in diesem Gen sind für das Rubinstein-Taybi-Syndrom (RTS) verantwortlich.<ref name="pmid7630403">{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Siehe auch

Einzelnachweise

<references />

Literatur

  • Rolf Knippers: Molekulare Genetik. 9. Auflage. Georg Thieme Verlag, 2006, ISBN 3-13-477009-1
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     | Vorlage:Cite book/Meldung
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       | Vorlage:Cite book/Meldung
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