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Arginase 1

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{{#if: | {{#if: s. UniProt| {{#if:663| {{#if: 322 Aminosäuren | {{#if: Homotrimer | {{#if: 2 Mn2+ | {{#if: | {{#if: 3 | {{#if: ARG1P05089Vorlage:CASRN60831388070ARG1 | {{#if: ARG1 | {{#if: P05089Vorlage:CASRN60831388070ARG1 | {{#if: | {{#if:| {{#if: | {{#if: 3.5.3.1HydrolaseHydrolyse einer C-N-BindungArginin + H2OOrnithin + Harnstoff | {{#if: 3.5.3.1Hydrolase| {{#if: | {{#if: | {{#if: Hydrolyse einer C-N-Bindung| {{#if: Arginin + H2O| {{#if: Ornithin + Harnstoff| {{#if: Wirbeltiere{{#if: P05089 | {{#ifeq: Leber-Arginase | NV ||1}}|}}| {{#if: P05089 | {{#ifeq: Leber-Arginase | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Wirbeltiere | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000118520ENSMUSG00000019987
{{#if: Arginase-1 | Arginase-1 | Arginase 1 }}
Arginase 1 }}
Bändermodell der Ratten-Arginase 1 komplexiert mit Hydroxyarginin, nach PDB 1HQF
Arginase 1 }}
Andere Namen

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Vorhandene Strukturdaten: s. UniProt }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 322 Aminosäuren

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Sekundär- bis Quartärstruktur Homotrimer

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Kofaktor 2 Mn2+

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Präkursor

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Isoformen 3

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Bezeichner
{{#if: | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:663 | ARG1 | ARG1}}{{#if: |, }} }}
Externe IDs

{{#if:ARG1 |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

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}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if:Vorlage:CASRN | 

 }}

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Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [1] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [2] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:3.5.3.1| 3.5.3.1}}{{#if: Hydrolase|, Hydrolase}} }}
MEROPS [3]}}
MEROPS [4]}}
Reaktionsart Hydrolyse einer C-N-Bindung 
 }}
Substrat Arginin + H2O 
 }}
Produkte Ornithin + Harnstoff 
 }}


}}

Vorkommen
{{#if: Leber-Arginase|Hovergen}}] Leber-Arginase|Hovergen}}]}} }} }}
Wirbeltiere }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 383
383 }} 
 {{ #if: 11846
11846 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000118520
ENSG00000118520 }} 
    {{ #if: ENSMUSG00000019987
ENSMUSG00000019987 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P05089
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P05089}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q61176
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q61176}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000045NM_007482
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000045
         | | NM_000045
         | |  }}
      {{ #if: NM_007482
         | | NM_007482
         | |  }}
    |}}
 |-
 {{#if: NP_000036NP_031508
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000036
         | | NP_000036
         | |  }}
      {{ #if: NP_031508
         | | NP_031508
         | |  }}
    |}}
 |-
 {{#if: 6131573144131584332102491520824927470
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 6 
        | {{#if: 131573144 
            | {{#if: 131584332 
                | |  #if: hg38 |?db=hg38|}}&position=chr6:131573144-131584332 Chr 6: {{#expr: 131573144 / 1000000 round 2}} – {{#expr: 131584332 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 10 
        | {{#if: 24915208 
            | {{#if: 24927470 
                | |  #if: mm10 |?db=mm10|}}&position=chr10:24915208-24927470 Chr 10: {{#expr: 24915208 / 1000000 round 2}} – {{#expr: 24927470 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 383
    | | 383
    | |  }}
 {{ #if: 11846
    | | 11846
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 383 

 {{#if: ENSG00000118520
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000118520 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P05089}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000045
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000045 }} 

 {{#if: NP_000036
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000036 }} 

 {{#if: 6 
   | {{#if: 131573144 
       | {{#if: 131584332 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr6:131573144-131584332 Chr 6: {{#expr: 131573144 / 1000000 round 2}} – {{#expr: 131584332 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 383 }} {{#if: Hausmaus 

    | {{#if: 11846ENSMUSG00000019987NM_007482NP_031508mm10102491520824927470Q61176 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 11846ENSMUSG00000019987NM_007482NP_031508mm10102491520824927470Q61176 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 383
    | | 383
    | |  }}
 {{ #if: 11846
    | | 11846
    | |  }}
 |-
 {{#if: ENSG00000118520ENSMUSG00000019987
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000118520
       || ENSG00000118520
       ||  }}
    {{ #if: ENSMUSG00000019987
       || ENSMUSG00000019987
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P05089
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P05089}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q61176
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q61176}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000045NM_007482
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000045
         | | NM_000045
         | |  }}
      {{ #if: NM_007482
         | | NM_007482
         | |  }}
    |}}
 |-
 {{#if: NP_000036NP_031508
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000036
         | | NP_000036
         | |  }}
      {{ #if: NP_031508
         | | NP_031508
         | |  }}
    |}}
 |-
 {{#if: 6131573144131584332102491520824927470
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 6 
        | {{#if: 131573144 
            | {{#if: 131584332 
                | |  #if: hg38 |?db=hg38|}}&position=chr6:131573144-131584332 Chr 6: {{#expr: 131573144 / 1000000 round 2}} – {{#expr: 131584332 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 10 
        | {{#if: 24915208 
            | {{#if: 24927470 
                | |  #if: mm10 |?db=mm10|}}&position=chr10:24915208-24927470 Chr 10: {{#expr: 24915208 / 1000000 round 2}} – {{#expr: 24927470 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 383
    | | 383
    | |  }}
 {{ #if: 11846
    | | 11846
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 383 

 {{#if: ENSG00000118520
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000118520 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P05089}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_000045
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000045 }} 

 {{#if: NP_000036
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000036 }} 

 {{#if: 6 
   | {{#if: 131573144 
       | {{#if: 131584332 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr6:131573144-131584332 Chr 6: {{#expr: 131573144 / 1000000 round 2}} – {{#expr: 131584332 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 383 }} {{#if: Hausmaus 

    | {{#if: 11846ENSMUSG00000019987NM_007482NP_031508mm10102491520824927470Q61176 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 11846ENSMUSG00000019987NM_007482NP_031508mm10102491520824927470Q61176 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:PDB 1hqf EBI.jpg||}}

Arginase 1 (auch: Leber-Arginase, ARG1) ist das Enzym, das den letzten Reaktionsschritt im Harnstoffzyklus der Wirbeltiere katalysiert. Die Arginasen sind eine Gruppe von Isozymen, die in allen Lebewesen vorkommen und den Abbau der Aminosäure Arginin zu Ornithin und Harnstoff bewerkstelligen. Beim Menschen können Mutationen im ARG1-Gen zu Arginasemangel, und dieser zu einem Harnstoffzyklusdefekt mit Hyperammonämie führen. Varianten von Arginase waren in Asthmapatienten mit Nebenwirkungen auf Beta-2-Sympathomimetika assoziiert. Eine andere Variante zeigte einen Zusammenhang mit dem Herzinfarkt-Risiko.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P05089}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Neutrophile Granulozyten modulieren die Immunantwort durch Sekretion von Arginase. In Psoriasisläsionen wird Arginase überexprimiert. Dies führt zu verminderter Verfügbarkeit von Stickstoffoxid im Gewebe, da Arginase mit NO-Synthase um Arginin konkurriert. Dieselbe Konkurrenz innerhalb von Macrophagen wird von intrazellulären Pathogenen wie Mycobacterium tuberculosis, Toxoplasma gondii und anderen ausgenutzt, um der Immunreaktion zu entgehen.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Die cAMP-abhängige Regulation der ARG1-Expression wird von Proteinkinase AI moduliert und ist auf Histon-Deacetylierung angewiesen.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Katalysierte Reaktion

Arginin + H2O ⇔ Ornithin + Harnstoff

Arginin wird zu Ornithin und Harnstoff hydrolysiert.

Weblinks

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Einzelnachweise

<references />

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