imported>ChemoBot: Entferne Parameter „Suchfunktion“ aus {{Infobox Chemikalie}} und bereinige Leerzeilen

2026-01-24T11:24:24Z

Entferne Parameter „Suchfunktion“ aus {{Infobox Chemikalie}} und bereinige Leerzeilen

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{{Infobox Chemikalie
| Strukturformel = [[Bild:JDTic.svg|300px|Strukturformel von JDTic]]
| Andere Namen = (3''R'')-7-Hydroxy-''N''-[(2''S'')-1-[(3''R'',4''R'')-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisochinolin-3-carboxamid
| Summenformel = C28H39N3O3
| CAS = {{CASRN|361444-66-8}}
| EG-Nummer =
| ECHA-ID =
| PubChem = 9956146
| ChemSpider = 8131755
| Beschreibung =
| Molare Masse = 465,626 g·[[mol]]−1
| Aggregat =
| Dichte = 
| Schmelzpunkt = 
| Siedepunkt = 
| Dampfdruck = 
| Löslichkeit =
| Brechungsindex =
| Quelle GHS-Kz = NV
| GHS-Piktogramme = {{GHS-Piktogramme|/}}
| GHS-Signalwort =
| H = {{H-Sätze|/}}
| EUH = {{EUH-Sätze|/}}
| P = {{P-Sätze|/}}
| Quelle P =
}}

'''JDTic''' ist ein [[Selektivität (Pharmakologie)|selektiver]] und hoch wirksamer κ-[[Opioidrezeptor]]-[[Antagonist (Pharmakologie)|Antagonist]]<ref>Thomas JB et al. (2001): Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity, ''[[Journal of Medicinal Chemistry]]'', 44(17):2687-90. PMID 11495579</ref><ref>Thomas JB et al. (2003): Identification of <nowiki>(3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]- 2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide</nowiki> as a novel potent and selective opioid kappa receptor antagonist, ''Journal of Medicinal Chemistry'', 46(14):3127-37. PMID 12825951</ref><ref>Cai TB et al (2008): Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist <nowiki>(3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl- 1-piperidinyl]methyl}- 2-methylpropyl)- 1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide (JDTic)</nowiki>, ''Journal of Medicinal Chemistry'', 51(6):1849-60. PMID 18307295</ref>, der in der Wissenschaft als experimenteller Wirkstoff und [[Ligand (Biochemie)|Ligand]] verwendet wird. Der über Wochen anhaltende Effekt des auch [[peroral]] wirksamen Antagonisten<ref>Carroll FI et al. (2004): Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist, ''[[European Journal of Pharmacology]]'', 501(1-3):111-9. PMID 15464069</ref> könnte auf der Aktivierung [[C-Jun-N-terminale Kinasen|c-Jun-N-terminaler Kinasen]] beruhen.<ref>Bruchas MR (2007): Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase, ''[[Journal of Biological Chemistry]]'', 282(41):29803-11. {{DOI|10.1074/jbc.M705540200}} PMID 17702750</ref> Verhaltenspharmakologische Studien legen nahe, dass JDTic antidepressiv, angstlösend<ref>Knoll AT et al. (2007): Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats, ''[[Journal of Pharmacology and Experimental Therapeutics]]'', 323(3):838-45. PMID 17823306</ref> und suchtlindernd<ref>Beardsley PM, Howard JL, Shelton KL, Carroll FI (2005): Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats, ''Psychopharmacology (Berlin)'', 183(1):118-26. {{DOI|10.1007/s00213-005-0167-4}} PMID 16184376</ref><ref>Carroll FI, Harris LS, Aceto MD (2005): Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model, ''European Journal of Pharmacology'', 524(1-3):89-94. PMID 16236279</ref><ref>Jackson KJ, Carroll FI, Negus SS, Damaj MI (2010): Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse, ''Psychopharmacology (Berl)'', 210(2):285-94. PMID 20232057</ref> wirkt.

== Einzelnachweise ==
<references />

[[Kategorie:Carbonsäureamid]]
[[Kategorie:Phenol]]
[[Kategorie:Alkylpiperidin]]
[[Kategorie:Tetrahydroisochinolin]]
[[Kategorie:Opioid]]

JDTic - Versionsgeschichte

imported>ChemoBot: Entferne Parameter „Suchfunktion“ aus {{Infobox Chemikalie}} und bereinige Leerzeilen