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top: Vorlagenfix: Entferne veraltete Parameter mit AWB

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{{Infobox Protein
| Name =
| Bild = Protein HBZ PDB 1jeb.png
| Bild_legende = Struktur des HBZ-Proteins
| PDB =
| Groesse =
| Kofaktor =
| Precursor =
| Struktur =
| Isoformen =
| HGNCid =
| Symbol = HBZ
| AltSymbols =
| OMIM = 142310
| UniProt =
| MGIid =
| Homolog_fam =
| Taxon =
| Taxon_Ausnahme =
| Orthologe =
}}

Die [[Protein-Untereinheit|Untereinheit]] '''Hämoglobin zeta''' ist ein [[Protein]], für welches das beim Menschen vorhandene HBZ-[[Gen]] codiert.<ref name="pmid2649166">{{cite journal | author = Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ | title = A review of the molecular genetics of the human alpha-globin gene cluster | journal = [[Blood (Zeitschrift)|Blood]] | language=en | volume = 73 | issue = 5 | pages = 1081–104 | year = 1989 | month = May | pmid = 2649166 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HBZ hemoglobin, zeta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3050 | language=en | accessdate=2012-05-19}}</ref>

Das zeta-Globin ist ein dem alpha-Globin ähnliches [[Hämoglobin]]. Das zeta-Globin-Polypeptid wird im [[Dottersack]] eines frühen [[Embryo]]s synthetisiert, während das alpha-Globin im Leben eines [[Fötus]] sowie eines Erwachsenen durchgehend produziert wird. Das zeta-Globin-Gen ist ein Mitglied des menschlichen alpha-globin-[[Gen-Cluster]]s, das fünf funktionale Gene und zwei [[Pseudogen]]e beinhaltet. Die Reihenfolge der Gene lautet: 5' – '''zeta''' – pseudozeta – [[HBM (Protein)|my]] – pseudoalpha-1 – [[Hämoglobin, alpha 2|alpha-2]] – [[Hämoglobin, alpha 1|alpha-1]] – [[HBQ1|theta1]] – 3'.<ref name="entrez" />

== Einzelnachweise ==
<references />

== Literatur ==
*{{cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin |journal=Crit. Rev. Biochem. Mol. Biol. |language=en |volume=30 |issue= 3 |pages= 165–96 |year= 1995 |pmid= 7555018 |doi=10.3109/10409239509085142 }}
*{{cite journal | author=Proudfoot NJ, Brownlee GG |title=3' non-coding region sequences in eukaryotic messenger RNA |journal=[[Nature]] |language=en |volume=263 |issue= 5574 |pages= 211–4 |year= 1976 |pmid= 822353 |doi=10.1038/263211a0 }}
*{{cite journal | author=Fougerousse F, Meloni R, Roudaut C, Beckmann JS |title=Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1) |journal=[[Nucleic Acids Research]] |language=en |volume=20 |issue= 5 |pages= 1165 |year= 1992 |pmid= 1549498 |doi=10.1093/nar/20.5.1165 | pmc=312136 }}
*{{cite journal | author=J. Hess, C. Perez-Stable, G. J. Wu, B. Weir, I. Tinoco, C. K. Shen |title=End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication |journal=J. Mol. Biol |language=en |volume=184 |issue= 1 |pages= 7–21 |year= 1985 |pmid= 2411938 |doi=10.1016/0022-2836(85)90039-7 }}
*{{cite journal | author=C. A. Marotta, B. G. Forget, S. M. Weissman, I. M. Verma, R. P. McCaffrey, D. Baltimore |title=Nucleotide Sequences of Human Globin Messenger RNA |journal=[[Proc. Natl. Acad. Sci. U.S.A.]] |language=en |volume=71 |issue= 6 |pages= 2300–4 |year= 1974 |pmid= 4135409 |doi=10.1073/pnas.71.6.2300 | pmc=388440 }}
*{{cite journal | author=Perez-Stable C, Ayres TM, Shen CK |title=Distinctive sequence organization and functional programming of an Alu repeat promoter |journal=Proc. Natl. Acad. Sci. U.S.A |language=en |volume=81 |issue= 17 |pages= 5291–5 |year= 1984 |pmid= 6089189 |doi=10.1073/pnas.81.17.5291 | pmc=391689 }}
*{{cite journal | author=Clegg JB, Gagnon J |title=Structure of the zeta chain of human embryonic hemoglobin |journal=Proc. Natl. Acad. Sci. U.S.A |language=en |volume=78 |issue= 10 |pages= 6076–80 |year= 1982 |pmid= 6171809 |doi=10.1073/pnas.78.10.6076 | pmc=348980 }}
*{{cite journal | author=Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G |title=[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |language=en |volume=362 |issue= 12 |pages= 1657–9 |year= 1982 |pmid= 6172357 |doi= }}
*{{cite journal | author=Aschauer H, Sanguansermsri T, Braunitzer G |title=[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |language=en |volume=362 |issue= 8 |pages= 1159–62 |year= 1982 |pmid= 6179844 |doi= }}
*{{cite journal | author=Proudfoot NJ, Gil A, [[Thomas Maniatis|Maniatis T]] |title=The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene |journal=[[Cell (Zeitschrift)|Cell]] |language=en |volume=31 |issue= 3 Pt 2 |pages= 553–63 |year= 1983 |pmid= 6297773 |doi=10.1016/0092-8674(82)90311-7 }}
*{{cite journal | author=Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ |title=Molecular basis of length polymorphism in the human zeta-globin gene complex |journal=Proc. Natl. Acad. Sci. U.S.A |language=en |volume=80 |issue= 16 |pages= 5022–6 |year= 1983 |pmid= 6308667 |doi=10.1073/pnas.80.16.5022 | pmc=384180 }}
*{{cite journal | author=M. M. Cohen-Solal, B. Authier, J. K. deRiel, M. J. Murnane, B. G. Forget |title=Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA |journal=DNA |language=en |volume=1 |issue= 4 |pages= 355–63 |year= 1983 |pmid= 6963223 |doi=10.1089/dna.1982.1.355 }}
*{{cite journal | author=Orkin SH, Michelson A |title=Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia |journal=Nature |language=en |volume=286 |issue= 5772 |pages= 538–40 |year= 1980 |pmid= 7402334 |doi=10.1038/286538a0 }}
*{{cite journal | author=J. Flint, K. Thomas, G. Micklem, H. Raynham, K. Clark, N. A. Doggett, A. King, D. R. Higgs |title=The relationship between chromosome structure and function at a human telomeric region |journal=[[Nat. Genet.]] |language=en |volume=15 |issue= 3 |pages= 252–7 |year= 1997 |pmid= 9054936 |doi= 10.1038/ng0397-252 }}
*{{cite journal | author=H. Y. Luo, X. L. Liang, C. Frye, M. Wonio, G. D. Hankins, D. H. Chui, B. P. Alter |title=Embryonic hemoglobins are expressed in definitive cells |journal=Blood |language=en |volume=94 |issue= 1 |pages= 359–61 |year= 1999 |pmid= 10381533 |doi= }}
*{{cite journal | author=R. J. Daniels, J. F. Peden, C. Lloyd, S. W. Horsley, K. Clark, C. Tufarelli, L. Kearney, V. J. Buckle, N. A. Doggett, J. Flint, D. R. Higgs |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 |journal=Hum. Mol. Genet. |language=en |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 }}
*{{cite journal | author=E. T. Lau, Y. K. Kwok, D. H. Chui, H. S. Wong, H. Y. Luo, M. H. Tang |title=Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures |journal=Prenat. Diagn |language=en |volume=21 |issue= 7 |pages= 529–39 |year= 2001 |pmid= 11494285 |doi= 10.1002/pd.81 }}

[[Kategorie:Sauerstofftransporter]]
[[Kategorie:Blutbestandteil]]
[[Kategorie:Codiert auf Chromosom 16 (Mensch)]]

HBZ (Protein) - Versionsgeschichte

imported>Antonsusi: /* top */ Vorlagenfix: Entferne veraltete Parameter mit AWB