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GRIA 4 - Versionsgeschichte
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<p><b>Neue Seite</b></p><div>{{Infobox Protein<br />
| Name = Glutamate receptor, ionotrophic, AMPA 4<br />
| Bild = <br />
| Bild_legende = <br />
| PDB = <br />
| Groesse = 882 Aminosäuren<br />
| Kofaktor = <br />
| Precursor = <br />
| Struktur = Homo-/Heterotetramer, multipass Membranprotein<br />
| Isoformen = <br />
| HGNCid = 4574<br />
| Symbol = GRIA4<br />
| AltSymbols = <br />
| OMIM = 138246<br />
| MGIid = 95811<br />
| UniProt = P48058<br />
| ATC-Code = <br />
| CAS = <br />
| CASergänzend = <br />
| DrugBank = <br />
| Wirkstoffklasse = <br />
| TCDB = 1.A.10<br />
| TranspText = glutamatgesteuerter Ionenkanal<br />
| EC-Nummer = <br />
| Peptidase_fam = <br />
| Kategorie = <br />
| Reaktionsart = <br />
| Substrat = <br />
| Produkte = <br />
| Homolog_fam = <br />
| Taxon = <br />
| Taxon_Ausnahme = <br />
| Orthologe = <br />
{{ Protein Orthologe<br />
| Spezies1 = Mensch<br />
| Spezies2 = Maus<br />
| S1_EntrezGene = 2893<br />
| S1_Ensembl = ENSG00000152578<br />
| S1_RefseqmRNA = NM_000829<br />
| S1_RefseqProtein = NP_000820<br />
| S1_GenLoc_db = <br />
| S1_GenLoc_chr = 11 <br />
| S1_GenLoc_start = 104986935<br />
| S1_GenLoc_end = 105355676<br />
| S1_Uniprot = P48058<br />
| S2_EntrezGene = 14802<br />
| S2_Ensembl = ENSMUSG00000025892<br />
| S2_RefseqmRNA = NM_019691<br />
| S2_RefseqProtein = NP_062665<br />
| S2_GenLoc_db = <br />
| S2_GenLoc_chr = 9<br />
| S2_GenLoc_start = 4417889<br />
| S2_GenLoc_end = 4796142<br />
| S2_Uniprot = Q8BXG8<br />
}}<br />
}}<br />
<br />
Der '''ionotrope Glutamate Rezeptor, AMPA 4''', auch bekannt als '''GRIA4''' oder '''GluR4''', ist ein menschliches [[Protein]].<ref name="entrez">{{cite web | title = Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2893| accessdate = 2010-12-31}}</ref><br />
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Dieses [[Membranprotein]] ist ein Mitglied der [[Glutaminsäure|glutamatgesteuerten]] [[Ionenkanal|Ionenkanäle]] und vermittelt eine schnelle exzitatorische Signalübertragung an [[Synapsen]]. Der Kanaltyp kennt [[AMPA-Rezeptor|AMPA]] als Agonisten. Das Gen, das für dieses Protein kodiert gilt als eines der zahlreichen [[Neurobiologische Schizophreniekonzepte#Genetik|Schizophrenie-Kandidatengene]]. Für GRIA 4 sind durch [[alternatives Spleißen]] erzeugte [[mRNA]]-Varianten bekannt, die für verschiedene Isoformen der Proteinuntereinheiten codieren.<ref name="entrez" /><br />
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== <!--== Empfohlene Literatur == * McNamara JO, Eubanks JH, McPherson JD, ''et al.'': ''Chromosomal localization of human glutamate receptor genes.'' in: J. Neurosci. vol. 12,7 pg. 2555–62 (1992) PMID 1319477 * Hardy M, Younkin D, Tang CM, ''et al.'': ''Expression of non-NMDA glutamate receptor channel genes by clonal human neurons.'' in: J. Neurochem. vol. 63,2 pg. 482–9 (1994) PMID 7518497 * Roche KW, Raymond LA, Blackstone C, Huganir RL: ''Transmembrane topology of the glutamate receptor subunit GluR6.'' in: J. Biol. Chem. vol. 269,16 pg. 11679–82 (1994) PMID 8163463 * Fletcher EJ, Nutt SL, Hoo KH, ''et al.'': ''Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4.'' in: Recept. Channels vol. 3,1 pg. 21–31 (1996) PMID 8589990 * Bonaldo MF, Lennon G, Soares MB: ''Normalization and subtraction: two approaches to facilitate gene discovery.'' in: Genome Res. vol. 6,9 pg. 791–806 (1997) PMID 8889548 * Ripellino JA, Neve RL, Howe JR: ''Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.'' in: Neuroscience vol. 82,2 pg. 485–97 (1998) PMID 9466455 * Carvalho AL, Kameyama K, Huganir RL: ''Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors.'' in: J. Neurosci. vol. 19,12 pg. 4748–54 (1999) PMID 10366608 * Chen L, Chetkovich DM, Petralia RS, ''et al.'': ''Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.'' in: Nature vol. 408,6815 pg. 936–43 (2001) PMID 11140673 * Hirbec H, Perestenko O, Nishimune A, ''et al.'': ''The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.'' in: J. Biol. Chem. vol. 277,18 pg. 15221–4 (2002) PMID 11891216 * Tomiyama M, Rodríguez-Puertas R, Cortés R, ''et al.'': ''Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.'' in: Synapse vol. 45,4 pg. 245–9 (2002) PMID 12125045 * Pasternack A, Coleman SK, Jouppila A, ''et al.'': ''Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain.'' in: J. Biol. Chem. vol. 277,51 pg. 49662–7 (2003) PMID 12393905 * Correia SS, Duarte CB, Faro CJ, ''et al.'': ''Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation.'' in: J. Biol. Chem. vol. 278,8 pg. 6307–13 (2003) PMID 12471040 * Strausberg RL, Feingold EA, Grouse LH, ''et al.'': ''Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.'' in: Proc. Natl. Acad. Sci. U.S.A. vol. 99,26 pg. 16899–903 (2003) PMID 12477932 * Makino C, Fujii Y, Kikuta R, ''et al.'': ''Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region.'' in: Am. J. Med. Genet. B Neuropsychiatr. Genet. vol. 116,1 pg. 17–22 (2003) PMID 12497607 * Coleman SK, Cai C, Mottershead DG, ''et al.'': ''Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein.'' in: J. Neurosci. vol. 23,3 pg. 798–806 (2003) PMID 12574408 * Pasternack A, Coleman SK, Féthière J, ''et al.'': ''Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain.'' in: J. Neurochem. vol. 84,5 pg. 1184–92 (2003) PMID 12603841 * Kawahara Y, Ito K, Sun H, ''et al.'': ''GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain.'' in: Brain Res. Mol. Brain Res. vol. 127,1-2 pg. 150–5 (2004) PMID 15306133 * Li G, Sheng Z, Huang Z, Niu L: ''Kinetic mechanism of channel opening of the GluRDflip AMPA receptor.'' in: Biochemistry vol. 44,15 pg. 5835–41 (2005) PMID 15823042 * Nuriya M, Oh S, Huganir RL: ''Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4.'' in: J. Neurochem. vol. 95,2 pg. 544–52 (2005) PMID 16190873 * Kimura K, Wakamatsu A, Suzuki Y, ''et al.'': ''Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.'' in: Genome Res. vol. 16,1 pg. 55–65 (2006) PMID 16344560--> Einzelnachweise ==<br />
<references /><br />
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[[Kategorie:Membrankanal|Gria 4]]<br />
[[Kategorie:Codiert auf Chromosom 11 (Mensch)]]</div>
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