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GRIA 3 - Versionsgeschichte
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<p><b>Neue Seite</b></p><div>{{Infobox Protein<br />
| Name = Glutamate receptor, ionotrophic, AMPA 3<br />
| Bild = <br />
| Bild_legende = <br />
| PDB = <br />
| Groesse = 866 Aminosäuren<br />
| Kofaktor = <br />
| Precursor = <br />
| Struktur = multipass Membranprotein; Homo-/Heterotetramer<br />
| Isoformen = Flip, Flop<br />
| HGNCid = 4573<br />
| Symbol = GRIA3<br />
| AltSymbols = GluR-3, GluR-C, AMPA-3<br />
| OMIM = 305915<br />
| MGIid = 95810<br />
| UniProt = P42263<br />
| ATC-Code = <br />
| CAS = <br />
| CASergänzend = <br />
| DrugBank = <br />
| Wirkstoffklasse = <br />
| TCDB = 1.A.10<br />
| TranspText = Glutamatgesteuerter Ionenkanal<br />
| EC-Nummer = <br />
| Peptidase_fam = <br />
| Kategorie = <br />
| Reaktionsart = <br />
| Substrat = <br />
| Produkte = <br />
| Homolog_fam = Glutamatrezeptor<br />
| Homolog_url = <br />
| Taxon = [[Bilateria]]<br />
| Taxon_Ausnahme = <br />
| Orthologe = <br />
{{Protein Orthologe<br />
| Spezies1 = Mensch<br />
| Spezies2 = Maus<br />
| S1_EntrezGene = 2892<br />
| S1_Ensembl = ENSG00000125675<br />
| S1_RefseqmRNA = NM_000828<br />
| S1_RefseqProtein = NP_000819<br />
| S1_GenLoc_db = <br />
| S1_GenLoc_chr = X<br />
| S1_GenLoc_start = 122145687<br />
| S1_GenLoc_end = 122452447<br />
| S1_Uniprot = P42263<br />
| S2_EntrezGene = 53623<br />
| S2_Ensembl = ENSMUSG00000001986<br />
| S2_RefseqmRNA = NM_016886<br />
| S2_RefseqProtein = NP_058582<br />
| S2_GenLoc_db = <br />
| S2_GenLoc_chr = X<br />
| S2_GenLoc_start = 37646141<br />
| S2_GenLoc_end = 37923227<br />
| S2_Uniprot = Q0VGS8<br />
}}<br />
}}<br />
<br />
Der ionotrope '''Glutamat-Rezeptor AMPA 3''' ''(Syn. GRIA3)'' gehört zur Gruppe der [[AMPA-Rezeptor]]en. Er ist ein menschliches [[Protein]].<ref name="entrez">{{cite web | title = Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2892| accessdate = 2010-12-31}}</ref><br />
<br />
Glutamat-Rezeptoren gehören zu den vorherrschenden exzitatorischen [[Neurotransmitter]]-Rezeptoren im Gehirn von Säugetieren. Sie sind heteromere Proteinkomplexe, die aus verschiedenen Untereinheiten bestehen. Jede Untereinheit besitzt eine transmembranäre Domäne. Sie bilden zusammen einen ligandengesteuerten Ionenkanal. Die Glutamat-Rezeptoren vom Typ GRIA 1-4 (auch GluR1-4) gehören aufgrund ihrer Aktivierbarkeit durch den Agonisten alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate zu den sogenannten [[AMPA-Rezeptor]]en. GRIA 3 wird auch auf Lymphozyten exprimiert<ref>Ganor Y, Besser M, Ben-Zakay N, ''et al.'': ''Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.'' in: J. Immunol. vol. 170,8 pg. 4362–72 (2003) PMID 12682273</ref> und wurde als Kandidatengen für verschiedene Störungen gehandelt, unter anderem Rett-Syndrom<ref>Amir R, Dahle EJ, Toriolo D, Zoghbi HY: ''Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.'' in: Am. J. Med. Genet. vol. 90,1 pg. 69–71 (2000) PMID 10602120</ref>, Rasmussen-Enzephalitis<ref>Rogers SW, Andrews PI, Gahring LC, ''et al.'': ''Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis.'' in: Science vol. 265,5172 pg. 648–51 (1994) PMID 8036512</ref>, bipolare Störung<ref>Gécz J, Barnett S, Liu J, ''et al.'': ''Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.'' in: Genomics vol. 62,3 pg. 356–68 (2000) PMID 10644433</ref> und das X-gebundene Mental-redardation-Syndrom [[Smith-Fineman-Myers-Syndrom]].<ref>Liu QJ, Gong YQ, Chen BX, ''et al.'': ''[Linkage analysis and mutation detection of GRIA3 in Smith--Fineman--Myers syndrome]'' in: Yi Chuan Xue Bao vol. 28,11 pg. 985–90 (2001) PMID 11725645</ref><br />
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<!--== Empfohlene Literatur ==<br />
* McNamara JO, Eubanks JH, McPherson JD, ''et al.'': ''Chromosomal localization of human glutamate receptor genes.'' in: J. Neurosci. vol. 12,7 pg. 2555–62 (1992) PMID 1319477<br />
* Hollmann M, Hartley M, Heinemann S: ''Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition.'' in: [[Science]] vol. 252,5007 pg. 851–3 (1991) PMID 1709304<br />
* Rampersad V, Elliott CE, Nutt SL, ''et al.'': ''Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins.'' in: [[Biochim. Biophys. Acta]] vol. 1219,2 pg. 563–6 (1994) PMID 7918660<br />
* Tomiyama M, Rodriguez-Puertas R, Cortés R, ''et al.'': ''Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization.'' in: Neuroscience vol. 75,3 pg. 901–15 (1997) PMID 8951883<br />
* Osten P, Srivastava S, Inman GJ, ''et al.'': ''The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs.'' in: Neuron vol. 21,1 pg. 99–110 (1998) PMID 9697855<br />
* Srivastava S, Osten P, Vilim FS, ''et al.'': ''Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP.'' in: Neuron vol. 21,3 pg. 581–91 (1998) PMID 9768844<br />
* Hayashi T, Umemori H, Mishina M, Yamamoto T: ''The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn.'' in: Nature vol. 397,6714 pg. 72–6 (1999) PMID 9892356<br />
* Aruscavage PJ, Bass BL: ''A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.'' in: RNA vol. 6,2 pg. 257–69 (2000) PMID 10688364<br />
* Gahring L, Carlson NG, Meyer EL, Rogers SW: ''Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation.'' in: J. Immunol. vol. 166,3 pg. 1433–8 (2001) PMID 11160179<br />
* Hirbec H, Perestenko O, Nishimune A, ''et al.'': ''The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.'' in: J. Biol. Chem. vol. 277,18 pg. 15221–4 (2002) PMID 11891216<br />
* Wyszynski M, Kim E, Dunah AW, ''et al.'': ''Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.'' in: Neuron vol. 34,1 pg. 39–52 (2002) PMID 11931740<br />
* Tomiyama M, Rodríguez-Puertas R, Cortés R, ''et al.'': ''Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.'' in: Synapse vol. 45,4 pg. 245–9 (2002) PMID 12125045<br />
* Strausberg RL, Feingold EA, Grouse LH, ''et al.'': ''Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.'' in: Proc. Natl. Acad. Sci. U.S.A. vol. 99,26 pg. 16899–903 (2003) PMID 12477932<br />
* Flajolet M, Rakhilin S, Wang H, ''et al.'': ''Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.'' in: Proc. Natl. Acad. Sci. U.S.A. vol. 100,26 pg. 16006–11 (2004) PMID 14663150<br />
* Kolleker A, Zhu JJ, Schupp BJ, ''et al.'': ''Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.'' in: Neuron vol. 40,6 pg. 1199–212 (2004) PMID 14687553--><br />
== Einzelnachweise ==<br />
<references /><br />
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[[Kategorie:Membrankanal]]<br />
[[Kategorie:Codiert auf Chromosom X (Mensch)]]</div>
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