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CTD-Phosphatase - Versionsgeschichte
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<p><b>Neue Seite</b></p><div>{{Infobox Protein<br />
| Name = <br />
| Bild = Protein_CTDP1_PDB_1onv.png<br />
| Bild_legende = <!-- nach {{PDB|ABCD}} --><br />
| PDB = {{PDB2|1J2X}}, {{PDB2|1ONV}}, {{PDB2|2K7L}}<br />
| Groesse = 961 Aminosäuren<br />
| Kofaktor = TFIIF<br />
| Precursor = <br />
| Struktur = Homodimer<br />
| Isoformen = 3<br />
| HGNCid = 2498<br />
| Symbol = CTDP1<br />
| AltSymbols = CCFDN, FCP1<br />
| GeneCards = CTDP1<br />
| OMIM = 604927<br />
| UniProt = Q9Y5B0<br />
| MGIid = 1926953<br />
| CAS = <br />
| CASergänzend = <br />
| ATC-Code = <!-- {{ATC|X99|XX99}} --><br />
| DrugBank = <br />
| Wirkstoffklasse = <br />
| TCDB = <br />
| TranspText = <br />
| EC-Nummer = 3.1.3.16<br />
| Kategorie = Phosphatase<br />
| Peptidase_fam = <br />
| Inhibitor_fam = <br />
| Reaktionsart = Lösung einer Phosphorsäureesterbindung<br />
| Substrat = Phosphoprotein + H<sub>2</sub>O<br />
| Produkte = Protein + Phosphat<br />
| Homolog_fam = <br />
| Taxon = [[Eukaryoten]]<ref>[http://www.ebi.ac.uk/interpro/IEntry?ac=IPR011947 InterPro-Eintrag]</ref><br />
| Taxon_Ausnahme = <br />
| Orthologe = {{ Protein Orthologe<br />
| Spezies1 = Mensch<br />
| Spezies2 = Hausmaus<br />
| S1_EntrezGene = 9150<br />
| S1_Ensembl = ENSG00000060069<br />
| S1_RefseqmRNA = NM_001202504<br />
| S1_RefseqProtein = NP_001189433<br />
| S1_GenLoc_db = hg38<br />
| S1_GenLoc_chr = 18<br />
| S1_GenLoc_start = 79679801<br />
| S1_GenLoc_end = 79756623<br />
| S1_Uniprot = Q9Y5B0<br />
| S2_EntrezGene = 67655<br />
| S2_Ensembl = ENSMUSG00000033323<br />
| S2_RefseqmRNA = NM_026295<br />
| S2_RefseqProtein = NP_080571<br />
| S2_GenLoc_db = mm10<br />
| S2_GenLoc_chr = 18<br />
| S2_GenLoc_start = 80407959<br />
| S2_GenLoc_end = 80469695<br />
| S2_Uniprot = Q7TSG2<br />
}}<br />
}}<br />
<br />
Die '''CTD-Phosphatase (FCP1)''' (genauer '''TFIIF-assoziierende CTD-Phosphatase''') ist das [[Enzym]], das in [[Eukaryoten]] während der [[Transkription (Biologie)|Transkription]] die [[Phosphat]]reste von Serin-2 und Serin-5 der [[Polymerase II]] entfernt, womit die Polymerase für die [[Elongation (Transkription)|Elongation]] (re-)aktiviert wird. Es handelt sich also um eine [[Phosphatase]]. Das Enzym ist beim Menschen in allen Gewebetypen zu finden. [[Mutation]]en im entsprechenden ''CTDP1''-[[Gen]] können zu erblichen multiplen Entwicklungsstörungen mit Katarakt, dem sogenannten [[CCFDN-Syndrom]] führen.<ref>{{UniProt|Q9Y5B0}}</ref><br />
<br />
Um ihre volle Aktivität zu erhalten, wird die CTD-Phosphatase selbst von [[Caseinkinase]] 2 phosphoryliert, und benötigt die RAP74-Untereinheit von [[TFIIF]] als [[Coenzym|Cofaktor]].<ref>{{Cite journal<br />
| doi = 10.1021/bi801549m<br />
| pmid = 19215094<br />
| volume = 48<br />
| issue = 9<br />
| pages = 1964–1974<br />
| last = Yang<br />
| first = Ao<br />
| coauthors = Karen L. Abbott, Alexandre Desjardins, Paola Di Lello, James G. Omichinski, Pascale Legault<br />
| title = NMR Structure of a Complex Formed by the Carboxyl-Terminal Domain of Human RAP74 and a Phosphorylated Peptide from the Central Domain of the FCP1 Phosphatase<br />
| journal = [[Biochemistry]]<br />
| date = 2009-03-10<br />
| language = en<br />
}}</ref><ref>{{Cite journal<br />
| pmid = 15723518<br />
| doi = 10.1021/bi047958h<br />
| volume = 44<br />
| issue = 8<br />
| pages = 2732–2745<br />
| last = Abbott<br />
| first = Karen L.<br />
| coauthors = Matthew B. Renfrow, Michael J. Chalmers, Bao D. Nguyen, Alan G. Marshall, Pascale Legault, James G. Omichinski<br />
| title = Enhanced Binding of RNAP II CTD Phosphatase FCP1 to RAP74 Following CK2 Phosphorylation<br />
| journal = Biochemistry<br />
| date = 2005-03-01<br />
| language = en<br />
}}<br />
</ref><br />
<br />
Die Phosphorylierung von FCP1 wird von den Proteinen Pin1 und Hce1 sowie vom [[Tat-Protein]] des HI-Virus gehemmt. FCP1 wird von der [[Arginin-Methyltransferase]] [[PRMT5]] methyliert und ein FCP1-PRMT5-Komplex methyliert [[Histon H4]].<ref>{{cite journal<br />
|pmid=14672652<br />
|doi=10.1016/j.jmb.2003.10.036<br />
|volume=335<br />
|issue=2<br />
|pages=415–24<br />
|last=Palancade<br />
|first=Benoit<br />
|coauthors=Nicholas F. Marshall, Alexandre Tremeau-Bravard, Olivier Bensaude, Michael E. Dahmus, Marie-Francoise Dubois<br />
|title=Dephosphorylation of RNA Polymerase II by CTD-phosphatase FCP1 is Inhibited by Phospho-CTD Associating Proteins<br />
|journal=[[Journal of Molecular Biology]]<br />
|date=2004-01-09<br />
| language = en<br />
}}</ref><ref>{{Cite journal<br />
| pmid = 15670829<br />
| doi = 10.1016/j.febslet.2004.12.045<br />
| volume = 579<br />
| issue = 3<br />
| pages = 683–689<br />
| last = Stefano Amente<br />
| coauthors = Giuliana Napolitano, Paolo Licciardo, Maria Monti, Piero Pucci, Luigi Lania, Barbara Majello<br />
| title = Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation<br />
| journal = [[FEBS Letters]]<br />
| date = 2005-01-31<br />
| language = en<br />
}}</ref><ref>{{Cite journal<br />
| pmid = 15723517<br />
| doi = 10.1021/bi047957p<br />
| volume = 44<br />
| issue = 8<br />
| pages = 2716–2731<br />
| last = Abbott<br />
| first = Karen L.<br />
| coauthors = Jacques Archambault, Hua Xiao, Bao D. Nguyen, [[Robert G. Roeder]], Jack Greenblatt, James G. Omichinski, Pascale Legault<br />
| title = Interactions of the HIV-1 Tat and RAP74 Proteins with the RNA Polymerase II CTD Phosphatase FCP1†<br />
| journal = Biochemistry<br />
| date = 2005-03-01<br />
| language = en<br />
}}</ref><br />
<br />
== Weblinks ==<br />
* {{Orphanet |ID=48431 |Name=Kongenitale Katarakt-Gesichtsdysmorphie-Neuropathie-Syndrom }}<br />
* Gopinathrao / reactome: ''[https://reactome.org/content/detail/R-HSA-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein]''<br />
<br />
== Einzelnachweise ==<br />
<references /><br />
<br />
[[Kategorie:Phosphatase|Ctdphosphatase]]<br />
[[Kategorie:Codiert auf Chromosom 18 (Mensch)]]</div>
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