https://wiki-de.moshellshocker.dns64.de/index.php?action=history&feed=atom&title=CREB-Binding-Protein
CREB-Binding-Protein - Versionsgeschichte
2026-06-02T10:21:01Z
Versionsgeschichte dieser Seite in Wikipedia (Deutsch) – Lokale Kopie
MediaWiki 1.43.8
https://wiki-de.moshellshocker.dns64.de/index.php?title=CREB-Binding-Protein&diff=1614594&oldid=prev
imported>Antonsusi: /* top */ Vorlagenfix: Entferne veraltete Parameter mit AWB
2026-03-01T15:22:18Z
<p><span class="autocomment">top: </span> Vorlagenfix: Entferne veraltete Parameter mit <a href="/index.php/Wikipedia:AWB" class="mw-redirect" title="Wikipedia:AWB">AWB</a></p>
<p><b>Neue Seite</b></p><div>{{Infobox Protein<br />
| Name = <br />
| Bild = <br />
| Bild_legende = <br />
| PDB = s. UniProt<!-- {{PDB2|1YY1}}, {{PDB2|ABCD}} --><br />
| Groesse = 2442 Aminosäuren<br />
| Kofaktor = <br />
| Precursor = <br />
| Struktur = <br />
| Isoformen = <br />
| HGNCid = 2348<br />
| Symbol = CREBBP<br />
| AltSymbols = <br />
| OMIM = 600140<br />
| UniProt = Q92793<br />
| MGIid = <br />
| CAS = <br />
| CASergänzend = <br />
| ATC-Code = <!-- {{ATC|X99|XX99}} --><br />
| DrugBank = <br />
| Wirkstoffklasse = <br />
| TCDB = <br />
| TranspText = <br />
| EC-Nummer = 2.3.1.48<br />
| Kategorie = Acetyltransferase<br />
| Peptidase_fam = <br />
| Inhibitor_fam = <br />
| Reaktionsart = Übertragung einer Acetylgruppe<br />
| Substrat = Histon + Acetyl-CoA<br />
| Produkte = Acetylhiston + CoA<br />
| Homolog_fam = CREBBP<br />
| Taxon = [[Euteleostomi]]<br />
| Taxon_Ausnahme = <br />
| Orthologe = <br />
}}<br />
<br />
Das '''C'''REB-'''B'''inding '''P'''rotein (CREB-Bindeprotein), kurz '''CBP''', ist ein Coaktivator der [[Transkription (Biologie)|Transkription]]. <br />
<br />
CBP stellt eine Verbindung zwischen dem [[Transkriptionsfaktor]] [[CREB]] und dem [[Transkriptionsstartpunkt]] her, indem es als [[Histon-Acetyltransferase]] (HAT, {{EC|2.3.1.48}}) die [[Chromatin]]-Struktur verändert, die dadurch aufgelockert wird. CBP zeigt Homologien zum ebenfalls als HAT wirkenden Protein p300. CBP und p300 acetylieren bevorzugt die [[Histon]]e H3 und H4.<br />
<br />
CBP ist ein Coaktivator allgemeiner Natur und wechselwirkt z.&nbsp;B. auch mit [[Transkriptionsfaktor]]en.<br />
<br />
== Struktur ==<br />
[[Datei:Structure CREBBP de.svg|500px|zentriert]]<br />
<br />
== Klinische Bedeutung ==<br />
Mutationen in diesem [[Gen]] sind für das [[Rubinstein-Taybi-Syndrom]] (RTS) verantwortlich.<ref name="pmid7630403">{{cite journal |author=Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ |year=1995 |month=July |title=Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP |journal=[[Nature]] |volume=376 |issue=6538 |pages=348–51 |bibcode=1995Natur.376..348P |doi=10.1038/376348a0 |pmid=7630403 |language=en}}</ref><br />
<br />
== Siehe auch ==<br />
* [[Histonmodifikation]]<br />
<br />
== Einzelnachweise ==<br />
<references /><br />
<br />
== Literatur ==<br />
* Rolf Knippers: ''Molekulare Genetik''. 9. Auflage. Georg Thieme Verlag, 2006, ISBN 3-13-477009-1<br />
* {{cite journal |author=Goldman PS, Tran VK, Goodman RH |year=1997 |title=The multifunctional role of the co-activator CBP in transcriptional regulation. |journal=Recent Prog. Horm. Res. |volume=52 |pages=103–19; discussion 119–20 |pmid=9238849 |language=en}}<br />
* {{cite journal |author=Marcello A, Zoppé M, Giacca M |year=2002 |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue=3 |pages=175–81 |doi=10.1080/152165401753544241 |pmid=11547919 |language=en}}<br />
* {{cite journal |author=Matt T |year=2002 |title=Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP). |journal=Acta Med. Austriaca |volume=29 |issue=3 |pages=77–9 |doi=10.1046/j.1563-2571.2002.02010.x |pmid=12168567 |language=en}}<br />
* {{cite journal |author=Combes R, Balls M, Bansil L, ''et al.'' |year=2002 |title=An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). |journal=Alternatives to laboratory animals : ATLA |volume=30 |issue=4 |pages=365–406 |pmid=12234245 |language=en}}<br />
* {{cite journal |author=Minghetti L, Visentin S, Patrizio M, ''et al.'' |year=2004 |title=Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. |journal=Neurochem. Res. |volume=29 |issue=5 |pages=965–78 |doi=10.1023/B:NERE.0000021241.90133.89 |pmid=15139295 |language=en}}<br />
* {{cite journal |author=Kino T, Pavlakis GN |year=2004 |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue=4 |pages=193–205 |doi=10.1089/104454904773819789 |pmid=15142377 |language=en}}<br />
* {{cite journal |author=Greene WC, Chen LF |year=2004 |title=Regulation of NF-kappaB action by reversible acetylation. |journal=Novartis Found. Symp. |volume=259 |pages=208–17; discussion 218–25 |doi=10.1002/0470862637.ch15 |pmid=15171256 |language=en}}<br />
* {{cite journal |author=Liou LY, Herrmann CH, Rice AP |year=2005 |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue=9 |pages=1767–75 |doi=10.1016/j.biocel.2004.02.018 |pmid=15183343 |language=en}}<br />
* {{cite journal |author=Pugliese A, Vidotto V, Beltramo T, ''et al.'' |year=2005 |title=A review of HIV-1 Tat protein biological effects. |journal=Cell Biochem. Funct. |volume=23 |issue=4 |pages=223–7 |doi=10.1002/cbf.1147 |pmid=15473004 |language=en}}<br />
* {{cite journal |author=Bannwarth S, Gatignol A |year=2005 |title=HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. |journal=Curr. HIV Res. |volume=3 |issue=1 |pages=61–71 |doi=10.2174/1570162052772924 |pmid=15638724 |language=en}}<br />
* {{cite journal |author=Le Rouzic E, Benichou S |year=2006 |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |pages=11 |doi=10.1186/1742-4690-2-11 |pmid=15725353 |pmc=554975 |language=en}}<br />
* {{cite journal |author=Gibellini D, Vitone F, Schiavone P, Re MC |year=2005 |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue=2 |pages=95–109 |pmid=16035254 |language=en}}<br />
* {{cite journal |author=Hetzer C, Dormeyer W, Schnölzer M, Ott M |year=2006 |title=Decoding Tat: the biology of HIV Tat posttranslational modifications. |journal=Microbes Infect. |volume=7 |issue=13 |pages=1364–9 |doi=10.1016/j.micinf.2005.06.003 |pmid=16046164 |language=en}}<br />
* {{cite journal |author=Peruzzi F |year=2006 |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |pages=708–17 |doi=10.2741/1829 |pmid=16146763 |language=en}}<br />
<br />
{{SORTIERUNG:Creb Binding Protein}}<br />
[[Kategorie:Epigenetik]]<br />
[[Kategorie:Transkriptionsfaktor]]<br />
[[Kategorie:Transferase]]<br />
[[Kategorie:Codiert auf Chromosom 16 (Mensch)]]</div>
imported>Antonsusi