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Thromboxansynthase – Wikipedia Zum Inhalt springen

Thromboxansynthase

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(Weitergeleitet von Thromboxan-Synthase)
{{#if: | {{#if: | {{#if:11609| {{#if: 533 Aminosäuren | {{#if: Monomer, multipass Membranprotein | {{#if: Häm | {{#if: | {{#if: | {{#if: TBXAS1CYP5A1P24557274180 | {{#if: TBXAS1CYP5A1 | {{#if: P24557274180 | {{#if: | {{#if:| {{#if: | {{#if: 5.3.99.5IsomeraseUmlagerungProstaglandin H2Thromboxan A2 | {{#if: 5.3.99.5Isomerase| {{#if: | {{#if: | {{#if: Umlagerung| {{#if: Prostaglandin H2| {{#if: Thromboxan A2| {{#if: Chordatiere{{#if: P24557 | {{#ifeq: Thromboxansynthase | NV ||1}}|}}| {{#if: P24557 | {{#ifeq: Thromboxansynthase | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Chordatiere | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000059377ENSMUSG00000029925
{{#if: | | Thromboxansynthase }}
[[Datei:|250x200px|{{#if: | | Thromboxansynthase }}]]
Thromboxansynthase }}
Andere Namen

{{{Andere Namen}}} }}

Vorhandene Strukturdaten: }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 533 Aminosäuren

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Sekundär- bis Quartärstruktur Monomer, multipass Membranprotein

}}

Kofaktor Häm

}}

Präkursor

}}

Isoformen

}}

Bezeichner
{{#if:CYP5A1 | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:11609 | TBXAS1 | TBXAS1}}{{#if:CYP5A1 |, CYP5A1}} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}} }}{{#invoke:TemplatePar|check

all= 1= opt= 2= 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

}}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | 

 }}

}}

Arzneistoffangaben
ATC-Code 
 }}
 {{#if:|
DrugBank [2] 
 }}
 {{#if:|
Wirkstoffklasse 
 }}

}}

Transporter-Klassifikation
TCDB [3] 
 {{#if: |
Bezeichnung 
 }}

}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:5.3.99.5| 5.3.99.5}}{{#if: Isomerase|, Isomerase}} }}
MEROPS [4]}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart Umlagerung 
 }}
Substrat Prostaglandin H2 
 }}
Produkte Thromboxan A2 
 }}


}}

Vorkommen
{{#if: Thromboxansynthase|Hovergen}}] Thromboxansynthase|Hovergen}}]}} }} }}
Chordatiere }}
}}

}}

Mensch Hausmaus
Entrez 
 {{ #if: 6916
6916 }} 
 {{ #if: 21391
21391 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000059377
ENSG00000059377 }} 
    {{ #if: ENSMUSG00000029925
ENSMUSG00000029925 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P24557
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P24557}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P36423
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36423}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001061NM_011539
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001061
         | | NM_001061
         | |  }}
      {{ #if: NM_011539
         | | NM_011539
         | |  }}
    |}}
 |-
 {{#if: NP_001052NP_035669
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001052
         | | NP_001052
         | |  }}
      {{ #if: NP_035669
         | | NP_035669
         | |  }}
    |}}
 |-
 {{#if: 713977705114002032563887540439084585
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 7 
        | {{#if: 139777051 
            | {{#if: 140020325 
                | |  #if: hg38 |?db=hg38|}}&position=chr7:139777051-140020325 Chr 7: {{#expr: 139777051 / 1000000 round 2}} – {{#expr: 140020325 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 6 
        | {{#if: 38875404 
            | {{#if: 39084585 
                | |  #if: mm10 |?db=mm10|}}&position=chr6:38875404-39084585 Chr 6: {{#expr: 38875404 / 1000000 round 2}} – {{#expr: 39084585 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 6916
    | | 6916
    | |  }}
 {{ #if: 21391
    | | 21391
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 6916 

 {{#if: ENSG00000059377
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000059377 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P24557}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001061
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001061 }} 

 {{#if: NP_001052
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001052 }} 

 {{#if: 7 
   | {{#if: 139777051 
       | {{#if: 140020325 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr7:139777051-140020325 Chr 7: {{#expr: 139777051 / 1000000 round 2}} – {{#expr: 140020325 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 6916 }} {{#if: Hausmaus 

    | {{#if: 21391ENSMUSG00000029925NM_011539NP_035669mm1063887540439084585P36423 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 21391ENSMUSG00000029925NM_011539NP_035669mm1063887540439084585P36423 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 6916
    | | 6916
    | |  }}
 {{ #if: 21391
    | | 21391
    | |  }}
 |-
 {{#if: ENSG00000059377ENSMUSG00000029925
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000059377
       || ENSG00000059377
       ||  }}
    {{ #if: ENSMUSG00000029925
       || ENSMUSG00000029925
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P24557
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P24557}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P36423
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36423}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_001061NM_011539
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_001061
         | | NM_001061
         | |  }}
      {{ #if: NM_011539
         | | NM_011539
         | |  }}
    |}}
 |-
 {{#if: NP_001052NP_035669
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_001052
         | | NP_001052
         | |  }}
      {{ #if: NP_035669
         | | NP_035669
         | |  }}
    |}}
 |-
 {{#if: 713977705114002032563887540439084585
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 7 
        | {{#if: 139777051 
            | {{#if: 140020325 
                | |  #if: hg38 |?db=hg38|}}&position=chr7:139777051-140020325 Chr 7: {{#expr: 139777051 / 1000000 round 2}} – {{#expr: 140020325 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 6 
        | {{#if: 38875404 
            | {{#if: 39084585 
                | |  #if: mm10 |?db=mm10|}}&position=chr6:38875404-39084585 Chr 6: {{#expr: 38875404 / 1000000 round 2}} – {{#expr: 39084585 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 6916
    | | 6916
    | |  }}
 {{ #if: 21391
    | | 21391
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 6916 

 {{#if: ENSG00000059377
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000059377 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P24557}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_001061
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_001061 }} 

 {{#if: NP_001052
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_001052 }} 

 {{#if: 7 
   | {{#if: 139777051 
       | {{#if: 140020325 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr7:139777051-140020325 Chr 7: {{#expr: 139777051 / 1000000 round 2}} – {{#expr: 140020325 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 6916 }} {{#if: Hausmaus 

    | {{#if: 21391ENSMUSG00000029925NM_011539NP_035669mm1063887540439084585P36423 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 21391ENSMUSG00000029925NM_011539NP_035669mm1063887540439084585P36423 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:||}}

Die Thromboxan-Synthase (TXAS) ist das Enzym, das die Umlagerung von Prostaglandin H2 zu Thromboxan A2 katalysiert. TXAS wird in Chordatieren produziert. Beim Menschen ist das Enzym in Thrombozyten, der Lunge, den Nieren, in der Milz und in Macrophagen zu finden. Das Reaktionsprodukt Thromboxan fördert die Verengung von Blutgefäßen und ist der natürliche Gegenspieler von Prostacyclin. Mutationen am TBXAS1-Gen können zu TXAS- und Thromboxanmangel, sowie zu einer (seltenen) Dysplasie, dem Ghosal-Syndrom, führen.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P24557}}{{#if:|Vorlage:Abrufdatum}}</ref>

TXAS ist Target bei der Behandlung chronisch-entzündlicher Darmerkrankungen, sowie bei der Blasenkrebs-Behandlung, um die Menge der eingesetzten Chemotherapeutika zu reduzieren. Auch bei Darmkrebs und Prostatakrebs ist die TXAS-Produktion erhöht.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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  }}Vorlage:Cite book/Meldung2{{#ifexpr: 0{{#ifeq:^^|^^||+1}}{{#ifeq:^^|^^||+1}}{{#ifeq:Nie D, Che M, Zacharek A, et al|^^||+1}}{{#ifeq:^^|^^||+1}} > 1
    | Vorlage:Cite book/Meldung
  }}</ref>

Katalysierte Reaktion

PGH2  ⇒  ThrA2

Prostaglandin H2 wird zu Thromboxan A2 umgelagert. Die Reaktion ist selbstregulierend.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Weblinks

[[b:{{#if:|{{{lang}}}:}}{{#if:Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Thromboxansynthase}}|Wikibooks: {{#if:|{{{2}}}|{{#if:Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Biochemie und Pathobiochemie: Arachidonsäure-Stoffwechsel|Thromboxansynthase}}}}]]{{#switch: 1

|1|= – Lern- und Lehrmaterialien |0|-= |X|x={{#switch: 0 

      |0|4|10|12|14|100=}}

|#default= – {{{suffix}}}

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  }}

Einzelnachweise

<references />

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